Down-regulation of MHC class I is a property common to papillomavirus E5 proteins
Down-regulation of MHC class I is a property common to papillomavirus E5 proteins
复制标题
DOI：
10.1016/j.virusres.2006.02.005
复制
发表时间：
2006-09-01
期刊：
影响因子：
5
通讯作者：
Campo, M. S.
中科院分区：
文献类型：
--
作者：
Ashrafi, G. H.;Brown, D. R.;Campo, M. S.
乳头瘤病毒用途的 E5 蛋白家族包含与细胞内膜区室相关的小疏水蛋白。 E5 蛋白的功能，尤其是 HPV 的功能，仍远未明确。我们报道了 BPV-1、BPV-4、HPV-16 和 HPV-6 的 E5 蛋白下调 MHC I 类，可能帮助病毒逃避宿主免疫反应。其他人描述了 HPV-2 E5 导致 MHC I 类下调。我们在这里报告，另一种 E5 蛋白，HPV-83 E5，同样下调 MHC I 类，并提出干扰 MHC I 类的表达、组装和/或运输是病毒进化的所有 E5 蛋白的共同特性，以规避宿主免疫监视，从而建立生产性感染。 (c) 2006 Elsevier B.V. 保留所有权利。
The E5 protein family of papillomavir-uses comprises small hydrophobic proteins which are associated with the cell endomembrane compartments. The functions of the E5 proteins, particularly those of HPV, are still far from clear. We have reported that the E5 proteins of BPV-1, BPV-4, HPV-16 and HPV-6 down-regulate MHC class I, potentially helping the virus evade the host immune response. Others have described MHC class I downregulation by HPV-2 E5. We report here that another E5 protein, HPV-83 E5, likewise down-regulates MHC class I and propose that interference with expression, assembly and/or transport of MHC class I is a common property of all E5 proteins evolved by the virus to circumvent host immunosurveillance and thus establish productive infection. (c) 2006 Elsevier B.V. All rights reserved.