Noradrenergic inputs mediate state dependence of auditory responses in the avian song system
Noradrenergic inputs mediate state dependence of auditory responses in the avian song system
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DOI：
10.1523/jneurosci.1951-04.2004
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发表时间：
2004-09-01
影响因子：
5.3
通讯作者：
Schmidt, MF
中科院分区：
文献类型：
--
作者：
Cardin, JA;Schmidt, MF
去甲肾上腺素在感觉加工的行为状态依赖性调节中起着复杂的作用。然而，前脑NE在调节高阶感觉活动中的作用尚未得到直接解决。在这项研究中，我们利用鸟类鸣叫系统的离散前馈组织来确定NE作用的位置和机制，这些作用是状态依赖的感觉加工调制的基础。我们已经开发了一种实验范式，在这种范式中，短暂的唤醒反复抑制了歌曲系统的听觉反应。通过在体内的药理学操作，我们发现将α -肾上腺素能拮抗剂输注到NIf （nidopallium的核界面），一个听觉前脑区域，阻断了这种状态依赖性调节。我们还证明了NE和肾上腺素能激动剂对歌曲系统听觉反应特性的剂量依赖性增强和抑制。我们的研究结果表明，在一个专门用于声乐学习的神经系统中，单个前脑区域的去甲肾上腺素能释放是听觉处理行为依赖调节的一种机制。
Norepinephrine (NE) plays a complex role in the behavioral state-dependent regulation of sensory processing. However, the role of forebrain NE action in modulating high-order sensory activity has not been directly addressed. In this study, we take advantage of the discrete, feedforward organization of the avian song system to identify a site and mechanism of NE action underlying state-dependent modulation of sensory processing. We have developed an experimental paradigm in which brief arousal repeatedly suppresses song system auditory responsiveness. Using pharmacological manipulations in vivo, we show that infusion of alpha-adrenergic antagonists into the NIf (nucleus interfacialis of the nidopallium), an auditory forebrain area, blocks this state-dependent modulation. We also demonstrate dose-dependent enhancement and suppression of song system auditory response properties by NE and adrenergic agonists. Our results demonstrate that noradrenergic release in a single forebrain area is a mechanism underlying behavioral state-dependent regulation of auditory processing in a neural system specialized for vocal learning.