Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis
Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis
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DOI：
10.1002/ptr.2988
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发表时间：
2010-05-01
影响因子：
7.2
通讯作者：
Seidel, Veronique
中科院分区：
文献类型：
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作者：
Gordien, Andrea Y.;Gray, Alexander I.;Seidel, Veronique
随着结核病成为世界范围内的主要细菌杀手，以及其他分枝杆菌疾病的增加，寻找新的抗分枝杆菌药物是及时的。在这项研究中，从苏格兰种源的植物，地衣和真菌内生菌的提取物进行了筛选，对金分枝杆菌和M。结核病H（37）Rv.对M.观察了Juniperus communis根和Cladonia arbuscula的提取物（MIC = 4 μ g/mL）以及从欧洲越橘（Vaccinium myrtillus）分离的真菌内生菌（MIC = 8 μ g/mL）对金黄色葡萄球菌的影响。对M.结核病的C. arbuscula、黑穗长耳草（Empetrum nigrum）、J.communis根、Calluna vulgaris地上部分、Myrica gale根和茎（100 μ g/mL时抑制率为93 - 99%）。还观察到了Xerocomus badius、Chalciporus piperatus、Suillus luteus和分离自C. vulgaris、E. nigrum、Vaccinium vitis-idaea和欧洲越橘（V myrtillus）。本研究所获得的结果，部分地提供了一些科学依据的传统使用的一些选定的植物在治疗结核病。他们还表明，从苏格兰植物中回收的真菌内生菌是值得进一步研究的抗分枝杆菌剂的来源。版权所有（C）2009约翰威利父子有限公司
With tuberculosis the leading bacterial killer worldwide and other mycobacterial diseases on the increase, the search for new antimycobacterial agents is timely. In this study, extracts from plants, lichens and fungal endophytes of Scottish provenance were screened for activity against Mycobacterium aurum and M. tuberculosis H(37)Rv. The best activity against M. aurum was observed for extracts of Juniperus communis roots and Cladonia arbuscula (MIC = 4 mu g/mL), and a fungal endophyte isolated from Vaccinium myrtillus (MIC = 8 mu g/mL). The best activity against M. tuberculosis was observed for extracts of C. arbuscula, Empetrum nigrum,J. communis roots, Calluna vulgaris aerial parts, Myrica gale roots and stems (93 to 99% inhibition at 100 mu g/mL). Potent antitubercular activity (90 to 96% inhibition at 100 mu g/mL) was also observed for the ethanol extracts of Xerocomus badius, Chalciporus piperatus, Suillus luteus and of endophytes isolated from C. vulgaris, E. nigrum, Vaccinium vitis-idaea and V myrtillus. The results obtained this study provide, in part, some scientific basis for the traditional use of some of the selected plants in the treatment of tuberculosis. They also indicate that fungal endophytes recovered from Scottish plants are a source of antimycobacterial agents worthy of further investigation. Copyright (C) 2009 John Wiley & Sons, Ltd.