Immunological characteristics and management considerations in obese patients with asthma.
Immunological characteristics and management considerations in obese patients with asthma.
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DOI：
10.1586/1744666x.2015.1040394
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发表时间：
2015
影响因子：
4.4
通讯作者：
Dixon AE
中科院分区：
文献类型：
--
作者：
Ather JL;Poynter ME;Dixon AE
肥胖与严重、控制不良的哮喘有关，治疗效果不如瘦弱哮喘患者。从肥胖和哮喘动物模型中获得的重要见解表明，不同形式的肥胖可能导致不同的气道疾病表现：肥胖与先天气道反应性增加和对空气过敏原和污染物挑战的反应改变有关。在人类中，至少有两大类肥胖哮喘患者已被确认：一类可能是肥胖特有的，另一类可能是由肥胖引起的过敏性哮喘。本文将讨论我们从动物和人类研究中了解到的肥胖哮喘的免疫学和病理生理基础，以及这可能如何指导治疗。
Obesity is associated with severe, poorly controlled asthma that does not respond as well to therapy as asthma in leaner asthmatics. Important insights gained from animal models of obesity and asthma suggests that different forms of obesity may lead to different manifestations of airway disease: obesity is associated with both innate increased airway reactivity and altered responses to aeroallergen and pollutant challenges. In humans, at least two broad groups of obese asthmatics have been recognized: one that is likely unique to obesity and another that is likely lean allergic asthma much complicated by obesity. This article will discuss what we have learned about the immunological and pathophysiological basis of asthma in obesity from animal and human studies, and how this might guide therapy.