Diagnosis of Acute Pulmonary Histoplasmosis by Antigen Detection
Diagnosis of Acute Pulmonary Histoplasmosis by Antigen Detection
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DOI：
10.1086/648421
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发表时间：
2009-12-15
影响因子：
11.8
通讯作者：
Wheat, L. J.
中科院分区：
文献类型：
--
作者：
Swartzentruber, S.;Rhodes, L.;Wheat, L. J.
背景资料。抗原检测在播散性组织胞浆菌病的诊断中是有用的，但在急性肺组织胞浆菌病(APH)中还没有研究。由于大多数中重度或重度APH患者需要治疗，因此抗原检测有助于快速诊断。对130例急性早幼粒细胞白血病患者进行组织支原体抗原检测。抗原性尿检出64.6%，抗原血症68.6%，抗体64.3%。同时检测尿液和血清标本，82.8%检出抗原，其中45.8%仅检出抗原血症；若同时检测抗原和抗体，阳性率为93.3%，仅检出抗原阳性者占35.7%。使用补体结合试验检测抗原血症、抗原尿和抗体为APH的诊断提供了一种敏感的、非侵入性的方法。
Background. Antigen detection, which has proven useful in diagnosis of disseminated histoplasmosis, has not been studied in acute pulmonary histoplasmosis (APH). Because treatment is indicated in most patients with moderately severe or severe APH, antigen detection for rapid diagnosis could be helpful.Methods. Histoplasma antigen detection was evaluated in 130 patients with APH.Results. Antigenuria was detected in 64.6%, antigenemia in 68.6%, and antibody in 64.3%. If both urine and serum specimens were tested, antigen was detected in 82.8%, of which 45.8% had antigenemia only; and if both antigen and antibody were measured, results were positive in 93.3%, of which antigen only was positive in 35.7%.Conclusions. Testing for antigenemia, antigenuria, and antibodies using the complement fixation test offers a sensitive, noninvasive method for diagnosis of APH.