Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases
Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases
复制标题
线粒体自噬的分子机制及其在神经退行性疾病中的作用
DOI：
10.1016/j.phrs.2020.105240
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发表时间：
2021-01-17
影响因子：
9.3
通讯作者：
Peng, Ying
中科院分区：
文献类型：
--
作者：
Li, Xinnan;Huang, Longjian;Peng, Ying
神经退行性疾病是老年人最常见的神经系统疾病，目前无法治愈，给家庭和社会造成巨大负担。线粒体是细胞的能量工厂，对神经元功能具有极其重要的影响。消除功能失调的线粒体对于线粒体代谢稳态、能量供应和神经元存活至关重要。最近的研究表明，受损的线粒体自噬可能导致受损线粒体的积累，从而导致神经退行性疾病的进展。本综述主要关注神经退行性疾病中的线粒体自噬、线粒体动力学及其异常变化，以及最近在临床前和临床研究中显示出前景的针对线粒体自噬的治疗策略。
Neurodegenerative diseases are the most common diseases of the nervous system in elderly people, which are currently incurable and cause great burden to families and societies. Mitochondria are the energy factory of the cell and have extremely important effects on neuronal function. The elimination of dysfunctional mitochondria is essential for the mitochondrial metabolic homeostasis, energy supply, and neuronal survival. Recent studies suggest that the impaired mitophagy may lead to the accumulation of damaged mitochondria and therefore contribute to the progression of neurodegenerative diseases. This review mainly focuses on mitophagy, mitochondrial dynamics, and their abnormal changes in neurodegenerative diseases, as well as the therapeutic strategies targeting mitophagy that have shown promise in recent preclinical and clinical studies.