THE ORAL RETENTION AND ANTIPLAQUE EFFICACY OF TRICLOSAN IN HUMAN VOLUNTEERS
THE ORAL RETENTION AND ANTIPLAQUE EFFICACY OF TRICLOSAN IN HUMAN VOLUNTEERS
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DOI：
10.1111/j.1365-2125.1987.tb03094.x
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发表时间：
1987-05-01
影响因子：
3.4
通讯作者：
WILLIAMS, PEO
中科院分区：
文献类型：
--
作者：
GILBERT, RJ;WILLIAMS, PEO
1含有0.2%（w/w）三氯生的抗牙菌斑牙膏显著抑制了12名志愿者的过夜牙菌斑生长。2使用1 g含0.2%（w/w）[3 H]-三氯生的牙膏后，36.3 ±。保留了1.4%的三氯生。3平均浓度（±. s.d.）牙膏使用后5分钟唾液中的平均浓度为8.16 ± 0.001。2.50μ g g g-1。4三氯生的唾液衰减曲线符合两相模型，t1/2值分别为0.45 h和2.42 h。5三氯生在给药后至少8 h存在于菌斑中，至少3 h存在于口腔粘膜中。
1 An antiplaque toothpaste containing 0.2% (w/w) triclosan significantly inhibited overnight plaque growth in 12 human volunteers. 2 After use of a 1 g quantity of the toothpaste containing 0.2% (w/w) [3H]-triclosan, 36.3 .+-. 1.4% of the triclosan was retained. 3 The mean concentration ( .+-. s.d.) achieved in saliva 5 min after toothpaste use was 8.16 .+-. 2.50 .mu.g g-1. 4 The saliva decay curve for triclosan was consistent with a two phase model with t1/2 values of 0.45 h and 2.42 h, respectively. 5 Triclosan was present in bacterial plaque for at least 8 h after dosage and in the oral mucosa for at least 3 h.