Toll and Toll-like receptor signalling in development
Toll and Toll-like receptor signalling in development
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DOI：
10.1242/dev.156018
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发表时间：
2018-05-01
期刊：
影响因子：
4.6
通讯作者：
Hidalgo, Alicia
中科院分区：
文献类型：
--
作者：
Anthoney, Niki;Foldi, Istvan;Hidalgo, Alicia
膜受体Toll和相关的Toll样受体（TLR）以其在先天免疫中的通用功能而闻名。然而，Toll/TLRs最初是在发育背景下发现的，最近的研究表明，Toll/TLRs在发育中发挥了以前未预料到的功能，调节细胞命运，细胞数量，神经回路连接和突触发生。此外，对Toll/TLR作用的分子机制的了解正在扩大，并强调Toll/TLR的功能超出了经典的NF-κ B通路，以调节突触处的细胞间通讯和信号传导。在这里，我们提供了Toll/TLR信号的概述，并讨论了这种信号通路如何调节跨物种发展的各个方面。
The membrane receptor Toll and the related Toll-like receptors (TLRs) are best known for their universal function in innate immunity. However, Toll/TLRs were initially discovered in a developmental context, and recent studies have revealed that Toll/TLRs carry out previously unanticipated functions in development, regulating cell fate, cell number, neural circuit connectivity and synaptogenesis. Furthermore, knowledge of their molecular mechanisms of action is expanding and has highlighted that Toll/TLRs function beyond the canonical NF-kappa B pathway to regulate cell-to-cell communication and signalling at the synapse. Here, we provide an overview of Toll/TLR signalling and discuss how this signalling pathway regulates various aspects of development across species.