Detection of oncogenic human papillomavirus in sporadic retinoblastoma
Detection of oncogenic human papillomavirus in sporadic retinoblastoma
复制标题
DOI：
10.1034/j.1600-0420.2003.00112.x
复制
发表时间：
2003-08-01
期刊：
影响因子：
--
通讯作者：
Villa, LL
中科院分区：
文献类型：
--
作者：
Palazzi, MA;Yunes, JA;Villa, LL
Purpose: To investigate the presence of human papillomavirus (HPV) DNA in tumour tissue from patients with unilateral retinoblastoma.Methods: Samples of paraffin-embedded tumour tissue from 43 children with unilateral retinoblastoma were collected to investigate the presence of HPV DNA using polymerase chain reaction (PCR) and dot blot hybridization.Results: Oncogenic HPV DNA types 16 and 35 were detected in 12 (27.9%) of 43 tumour specimens. A higher frequency of differentiated tumours (63.3%) was observed among the HPV-positive tumours.Conclusions: Future studies are necessary to demonstrate an association between HPV and sporadic retinoblastoma.
