Social reward-conditioned place preference: A model revealing an interaction between cocaine and social context rewards in rats
Social reward-conditioned place preference: A model revealing an interaction between cocaine and social context rewards in rats
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DOI：
10.1016/j.drugalcdep.2008.02.013
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发表时间：
2008-08-01
影响因子：
4.2
通讯作者：
Neisewander, Janet L.
中科院分区：
文献类型：
--
作者：
Thiel, Kenneth J.;Okun, Alec C.;Neisewander, Janet L.
最近药物滥用研究的一个重点是社会互动对药物效果的影响。因此，本研究考察了条件性位置偏爱(CPP)作为评估青春期大鼠药物和社会奖励之间相互作用的模型。检查了建立社会奖励CPP的参数，包括每天条件训练的次数(1或2次)，总的训练次数(2，8或16次)，以及训练的持续时间(10或30分钟)。随后，考察了可卡因和右美沙芬对社会奖赏-CPP和游戏行为的影响。结果表明，社会奖励-CPP(即对先前与老鼠配对的环境的偏好转变)在每天1或2次条件反射训练以及10分钟或30分钟训练中相似；但社会奖励-CPP随着社会配对数量的增加而增加。此外，低剂量的可卡因(2毫克/公斤，ip)和少量的社会配对(2对)在单独检查时无法产生CPP，但一起产生了强大的CPP，证明了这些奖励之间的相互作用。非奖励性药物右美沙芬(30 mg/kg，ip)未能提高社会奖赏-CPP，这表明药物增强型社会奖赏-CPP是针对奖励性药物的。令人惊讶的是，在药物幼稚的动物中，游戏行为和偏好转变之间没有关系。此外，可卡因抑制了游戏行为，尽管提高了社会奖励-CPP，这表明除了游戏行为之外，社交互动的其他方面可能有助于社会奖励。这一发现对于理解社会环境对青春期可卡因奖励的影响具有重要意义。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
A recent thrust in drug abuse research is the influence of social interactions on drug effects. Therefore, the present study examined conditioned place preference (CPP) as a model for assessing interactions between drug and social rewards in adolescent rats. Parameters for establishing social reward-CPP were examined, including the number of conditioning sessions/day (1 or 2), the total number of sessions (2, 8, or 16), and the duration of sessions (10 or 30 min). Subsequently, the effects of cocaine or dextromethorphan on social reward-CPP and play behavior were examined. The results demonstrate that social reward-CPP (i.e., preference shift for an environment paired previously with a rat) was similar using either 1 or 2 conditioning sessions/day and either 10 or 30 min sessions; however, social reward-CPP increased as the number of social pairings increased. Additionally, a low dose of cocaine (2 mg/kg, IP) and a low number of social pairings (2 pairings) failed to produce CPP when examined alone, but together produced a robust CPP, demonstrating an interaction between these rewards. The non-rewarding drug, dextromethorphan (30 mg/kg, IP), failed to enhance social reward-CPP, suggesting that drug-enhanced social reward-CPP is specific to rewarding drugs. Surprisingly, there was no relationship between play behaviors and preference shift in drug-naive animals. Furthermore, cocaine inhibited play behavior despite enhancing social reward-CPP, suggesting that aspects of social interaction other than play behavior likely contribute to social reward. The findings have important implications for understanding the influence of social context on cocaine reward during adolescence. (C) 2008 Elsevier Ireland Ltd. All rights reserved.