RIB PERICHONDRIAL GRAFTS FOR THE REPAIR OF FULL-THICKNESS ARTICULAR-CARTILAGE DEFECTS - A MORPHOLOGICAL AND BIOCHEMICAL-STUDY IN RABBITS
RIB PERICHONDRIAL GRAFTS FOR THE REPAIR OF FULL-THICKNESS ARTICULAR-CARTILAGE DEFECTS - A MORPHOLOGICAL AND BIOCHEMICAL-STUDY IN RABBITS
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DOI：
10.2106/00004623-198567060-00013
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发表时间：
1985-01-01
影响因子：
5.3
通讯作者：
AKESON, WH
中科院分区：
文献类型：
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作者：
AMIEL, D;COUTTS, RD;AKESON, WH
研究了软骨膜移植物在关节软骨缺损中的应用，并对新形成的软骨进行了表征。在兔模型中，肋骨软骨膜用于修复股骨髁全层缺损。然后在移植后6周和12周对修复质量进行组织学和生物化学评价。在50%的家兔中获得了不可接受的结果。这些失败是由于髁突骨折20%，移植物附着失败20%，感染10%。移植技术必须不断改进，以增加具有相对正常化学成分的新软骨填充关节软骨缺损的成功移植百分比。成功的移植物增殖以用新软骨填充全层缺损，新软骨具有与透明软骨相似的生物化学特征。局部关节软骨损伤，如剥脱性骨软骨炎或股骨头坏死，可以通过软骨膜移植治疗。骨关节炎或小关节骨关节炎的有限病变也可能适合这种治疗。
The use of perichondrial grafts were investigated in articular cartilage defects and to characterize the newly formed cartilage. In a rabbit model, rib perichondrium was used to repair full-thickness defects in the femoral condyle. The quality of repair was then evaluated histologically and biochemically at 6 and 12 wk after grafting. Unacceptable results were obtained in 50% of the rabbits. These failures were due to condylar fracture in 20%, failure of graft attachment in 20% and infection in 10%. The technique of grafting must be improving to increase the percentage of successful grafts in which neocartilage with a relatively normal chemical composition fills the articular cartilage defect. Successful grafts proliferate to fill the full-thickness defect with neocartilage, which has biochemical characteristics that are similar to those of hyaline cartilage. Localized articular-cartilage lesions such as osteochondritis dissecans or osteonecrosis of the femoral head may be treatable by grafting with perichondrium. Limited lesions of osteoarthritis or osteoarthritis of small joints may also be amenable to this treatment.