INVIVO LUNG LAVAGE AS AN EXPERIMENTAL-MODEL OF THE RESPIRATORY-DISTRESS SYNDROME
INVIVO LUNG LAVAGE AS AN EXPERIMENTAL-MODEL OF THE RESPIRATORY-DISTRESS SYNDROME
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DOI：
10.1111/j.1399-6576.1980.tb01541.x
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发表时间：
1980-01-01
影响因子：
2.1
通讯作者：
VOGEL, J
中科院分区：
文献类型：
--
作者：
LACHMANN, B;ROBERTSON, B;VOGEL, J
使用成年豚鼠，开发了一种实验模型，其中肺泡表面活性剂磷脂通过在体内重复肺灌洗去除，并且其中通过人工通气确保动物的短期存活。血气、肺力学参数、组织学和EM结果表明，灌洗过程诱导了类似于人类成人呼吸窘迫综合征的状况。该技术可用于评价药物制剂和各种形式的人工通气建议治疗这种疾病。
Using adult guinea-pigs, an experimental model was developed in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and EM findings indicate that the lavage procedure induces a condition similar to the human adult respiratory distress syndrome. This technique might be used for evaluation of pharmacological agents and various forms of artificial ventilation suggested for treatment of this disease.