Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis
Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis
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DOI：
10.4238/2012.november.12.2
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发表时间：
2012-01-01
影响因子：
0.4
通讯作者：
He, Y. C.
中科院分区：
文献类型：
--
作者：
Liu, B. M.;Liu, T. M.;He, Y. C.
XRCC1 Arg399Gln 多态性与胃癌易感性之间的关联已得到研究；总体而言，结果尚无定论。我们对 13 项病例对照研究进行了荟萃分析，其中包括 3278 例病例和 6243 例对照。使用具有 95% 置信区间 (95%CI) 的粗比值比 (OR) 来评估这种可能的关联。我们没有发现 XRCC1 Arg399Gln 多态性与胃癌风险之间存在显着关联的证据（在加性遗传模型中，OR = 0.986，95%CI = 0.831-1.156，在显性遗传模型中，OR = 1.044，95%CI = 0.890-1.224，在隐性遗传模型中，OR = 0.975， 95%CI = 0.894-1.063）。我们得出结论，XRCC1 Arg399Gln 多态性不是发生胃癌的危险因素。
Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a significant association between the XRCC1 Arg399Gln polymorphism and gastric cancer risk (in the additive inheritance model, OR = 0.986, 95%CI = 0.831-1.156, in the dominant inheritance model, OR = 1.044, 95%CI = 0.890-1.224 and in the recessive inheritance model, OR = 0.975, 95%CI = 0.894-1.063). We conclude that the XRCC1 Arg399Gln polymorphism is not a risk factor for developing gastric cancer.