Molecular aspects of T-cell differentiation
Molecular aspects of T-cell differentiation
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DOI：
10.1258/0007142001903634
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发表时间：
2000-01-01
影响因子：
6.7
通讯作者：
Avni, O
中科院分区：
文献类型：
--
作者：
Rao, A;Avni, O
分化的辅助性T细胞1(Th1)和辅助性T细胞2(Th2)在细胞因子的表达模式上表现出显著的差异。这个过程分别由抗原和细胞因子IL-12和IL-4刺激启动，需要抗原诱导的转录因子如NFAT和细胞因子诱导的转录因子如IL-12诱导的STAT4和IL-4诱导的STAT6。这导致了亚群特异性转录因子的诱导和维持，包括Th1细胞中的T-bet和Th2细胞中的GATA3，这些转录因子参与确保T细胞对Th1或Th2谱系的承诺。在这里，我们回顾了介导T细胞分化的信号通路和转录因子，并描述了已知伴随这一过程的染色质结构、基因座可及性和DNA甲基化的表观遗传学变化。
Differentiated T helper 1 (Th 1) and T helper 2 (Th2) T-cells show striking differences in their patterns of cytokine expression. This process is initiated by stimulation with antigen and the cytokines IL-12 and IL-4, respectively, and requires antigen-induced transcription factors such as NFAT and cytokine-induced transcription factors such as STAT4, induced by IL-12, and STAT6, induced by IL-4. This results in induction and maintained expression of subset-specific transcription factors including T-bet in Th1 cells and GATA3 in Th2 cells, which are involved in ensuring the commitment of T-cells to Th1 or Th2 lineages. Here we review the signalling pathways and transcription factors that mediate T-cell differentiation, and describe the epigenetic changes in chromatin structure, locus accessibility and DNA methylation that are known to accompany this process.