Inflammatory Markers in Umbilical Cord Blood from Small-For-Gestational-Age Newborns
Inflammatory Markers in Umbilical Cord Blood from Small-For-Gestational-Age Newborns
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DOI：
10.3109/15513815.2013.879239
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发表时间：
2014-01-01
影响因子：
1.1
通讯作者：
Schmiegelow, Kjeld
中科院分区：
文献类型：
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作者：
Lausten-Thomsen, Ulrik;Olsen, Marianne;Schmiegelow, Kjeld
本研究通过检测小于胎龄儿(SGA)和胎龄儿(AGA)脐带血中炎症标志物的水平，探讨炎症在胎儿宫内发育迟缓中的作用。采用标准方法检测足月或近月儿(胎龄36周)、胎龄儿(45例)和对照组(45例)的白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)和C反应蛋白(CRP)水平。患有母体慢性病、糖尿病或先兆子痫的婴儿被排除在外。SGA被定义为低于预期期限和性别的两个标准派生。在多因素回归分析中，SGA组脐血IL-6浓度显著升高(平均值4.56vs.2.38，p=0.002)。结果表明，与AGA婴儿相比，SGA婴儿脐带血中的炎性标志物升高，从而提示胎儿宫内生长受限(IUGR)中存在炎性成分。
This study investigates the role of inflammation in intrauterine growth retardation by exploring the levels of inflammatory markers in umbilical cord blood from neonates who were born small-for-gestational-age (SGA) and comparing them to neonates who were born appropriate-for-gestational-age (AGA). Interleukin 6 (IL-6), Tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP) were measured by standard methods in term or near-term (gestational age >36 weeks) neonates born SGA (n= 45) and a matched group of neonates born AGA (n = 45). Infants exposed to maternal chronic diseases, diabetes or pre-eclampsia were excluded. SGA was defined as two standard derivations below the expected for term and gender. In multivariate regression analyses significant elevation in cord blood concentration of IL-6 was demonstrated in the SGA group (mean 4.56 vs. 2.38, p = 0.002). The results indicate the presence of elevated inflammatory markers in the cord blood from SGA infants compared to AGA infants, and consequently the results suggest an inflammatory component in intrauterine growth restriction (IUGR).