Transgenic mice expressing the βAPP695SWE mutation:: effects on exploratory activity, anxiety, and motor coordination
Transgenic mice expressing the βAPP695SWE mutation:: effects on exploratory activity, anxiety, and motor coordination
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DOI：
10.1016/s0006-8993(03)02694-5
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发表时间：
2003-07-04
期刊：
影响因子：
2.9
通讯作者：
Fukuchi, K
中科院分区：
文献类型：
--
作者：
Lalonde, R;Lewis, TL;Fukuchi, K
在探索活动和运动协调测试中评估了具有瑞典突变的betaAPP转基因在小鼠中的功能后果。β APP（695）SWE（Tg2576）转基因小鼠的特征在于新皮质和海马中的Abeta斑块形成。与对照年龄和性别的非转基因小鼠相比，17个月大的betaAPP（695）SWE转基因小鼠显示出受损的自发交替，在开放领域的外周部分活动水平增加，并在高架十字迷宫中焦虑减少。这些结果类似于在一些阿尔茨海默病患者中观察到的抑制控制的丧失。这些措施可能会被添加到认知功能障碍，作为Abeta疫苗接种和其他实验疗法的试验场。(C)2003 Elsevier Science B.V.保留所有权利。
The functional consequences of the betaAPP transgene with the Swedish mutation in mice were assessed in tests of exploratory activity and motor coordination. The betaAPP(695)SWE (Tg2576) transgenic mice are characterized by Abeta plaque formation in the neocortex and hippocampus. By comparison to non-transgenic mice controlled for age and gender, 17-month-old betaAPP(695)SWE transgenic mice displayed impaired spontaneous alternation, increased activity levels in the peripheral part of the open-field, and reduced anxiety in the elevated plus-maze. These results are similar to the loss of inhibitory control observed in some patients with Alzheimer's disease. These measures may be added to cognitive dysfunctions as testing ground for Abeta vaccination and other attempts at experimental therapies. (C) 2003 Elsevier Science B.V. All rights reserved.