Early Hemolysis Within Human Intracerebral Hematomas: an MRI Study
Early Hemolysis Within Human Intracerebral Hematomas: an MRI Study
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人脑内血肿的早期溶血：MRI 研究
DOI：
10.1007/s12975-018-0630-2
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发表时间：
2019-02-01
影响因子：
6.9
通讯作者：
Huang, Yining
中科院分区：
文献类型：
--
作者：
Liu, Ran;Li, Haijiao;Huang, Yining
大鼠脑出血模型24 h内血肿发生早期溶血。本研究利用MRI探讨脑出血患者早期溶血的发生率及早期溶血与血肿周围水肿的关系。30例脑出血患者在发病24小时内前瞻性入组。所有患者入院时均行颅脑CT检查。第1天和第14天分别进行头颅MRI T2 flair加权成像和T2*加权成像。研究T2*加权图像上非低信号病变的演变及非低信号病变体积与血肿周围水肿体积的关系。分析15例患者的MRI图像。入院时中位血肿体积为16.3 ml。所有患者在脑出血发病24小时内进行了基线MRI检查，在T2*加权图像上显示血肿内有非低信号病变。T2*加权图像上非低信号病变体积第1天为6.0 (8.9)ml，第14天为8.6 (17.3)ml。第1天和第14天，绝对血肿周围水肿体积分别为16.0 (17.9)ml和24.8 (27.5)ml。非低信号T2*病变与第1天、第14天血肿周围水肿量呈线性相关（p< 0.01）。血肿的早期溶血发生在人类身上，有助于血肿周围水肿的发展。
Early hemolysis occurs in the hematoma within 24 h in rat model of intracerebral hemorrhage (ICH). The present study investigated the prevalence of early hemolysis in ICH patients using MRI and the relationship between early hemolysis and perihematomal edema. Thirty ICH patients were prospectively enrolled within 24 h of onset. All patients had cranial CT on admission. Cranial MRI with T2 FLAIR-weighted imaging and T2*-weighted imaging were undertaken at days 1 and 14. The evolution of a non-hypointense lesion on T2*-weighted images and the relationship between the volume of that non-hypointense lesion and perihematomal edema volume were investigated. MRI images of 15 patients were analyzed. The median hematoma volume was 16.3 ml on admission. All patients underwent a baseline MRI within 24 h of ICH onset and showed a non-hypointense lesion within the hematoma on T2*-weighted images. The volume of non-hypointense lesion on T2*-weighted image was 6.0 (8.9) ml at day 1 and 8.6 (17.3) ml at day 14. The absolute perihematomal edema volume was 16.0 (17.9) ml and 24.8 (27.5) ml at days 1 and 14, respectively. There was a linear correlation between non-hypointense T2* lesion and perihematomal edema volume at day 1 and day 14 (p< 0.01). Early hemolysis in the hematoma occurs in humans and contributes to the development of perihematomal edema.