A Review on Recent Trends in Oral Drug Delivery-Fast Dissolving Formulation Technology

A Review on Recent Trends in Oral Drug Delivery-Fast Dissolving Formulation Technology
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口服给药速溶制剂技术最新趋势综述

DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
P. Sharma
P. Sharma
中科院分区：
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文献类型：
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作者：
Shobhit Kumar;S. Gupta;P. Sharma

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摘要：随着药物科学家对与药物作用相关的生物化学和物理化学性质的更好理解，药物传递系统变得越来越简单。快速溶解片剂（FDTs）由于更好的患者依从性而变得流行，并且优于传统的胶囊和片剂。当FDT放在舌头上时，它会迅速分解或溶解（在几秒钟内），而无需咀嚼或水。各种FDT产品在20世纪80年代进入市场。他们的需求正在逐步增加，他们的产品管道正在迅速加强。最近的FDT生产技术有助于在患有吞咽困难的患者中方便地给药。本文综述了FDTs制剂的特性、制备技术和专利技术。关键词：吞咽困难%快速崩解剂%快速溶解剂%崩解时间%冻干剂%直接压片%崩解剂
Abstract: As pharmaceutical scientists are attaining a bett er understanding of biochemical and physicochemicalproperties related to the drug action, the drug delivery systems are becoming simple. Fast dissolving tablets(FDTs) have become popular due to better patient compliance and preferred over conventional capsules andtablets. When FDT is put on the tongue, it disintegrates or dissolves rapidly (in seconds) without chewing orwater. Various FDT products entered into the market in 1980s. Their demand is progressively increasing andtheir product pipelines are speedily intensifying. Recent FDT production techniques have helped n imanagement of convenient dosing in patients suffering with dysphagia. The aim of this review article is to givean overview on desired characteristics, preparation techniques and patented technologies of FDTs formulation. Key words: Dysphagia % Fast Disintegrating% Fast Dissolving % Disintegration Time % Lyophilization % Direct Compression % Disintegrants INTRODUCTION