Chemoresistance in falciparum malaria
Chemoresistance in falciparum malaria
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DOI：
10.1016/j.pt.2003.08.001
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发表时间：
2003-10-01
影响因子：
9.6
通讯作者：
Meyer, CG
中科院分区：
文献类型：
--
作者：
May, J;Meyer, CG
热带国家日益面临恶性疟原虫感染的耐药性负担。过去四十年来，撒哈拉以南非洲地区五岁以下儿童总体死亡率下降，而非洲儿童疟疾相关死亡率却有所上升。这场灾难很大程度上可归因于大多数疟疾流行国家的抗疟药物耐药性。恶性疟原虫、感染的耐药原理和机制，以及新药和药物组合的开发和评价，是当前疟疾研究和控制策略的主要关注点。
Tropical countries increasingly face the burden of drug resistance in Plasmodium falciparum infections. Malaria-related mortality of African children rises in contrast to the decline of the overall mortality of children under five years of age in sub-Saharan Africa within the past four decades. The disaster can largely be attributed to antimalarial drug resistance in most malaria-endemic countries. The principles and mechanisms of chemoresistance in Plasmodium falciparum, infections, in addition to the development and evaluation of new drugs and drug combinations, are major concerns of current malaria research and control strategies.