Modeling muscle function using experimentally determined subject-specific muscle properties.
Modeling muscle function using experimentally determined subject-specific muscle properties.
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DOI：
10.1016/j.jbiomech.2021.110242
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发表时间：
2021-03-05
影响因子：
2.4
通讯作者：
Biewener AA
中科院分区：
文献类型：
--
作者：
Wakeling JM;Tijs C;Konow N;Biewener AA
肌肉模型通常基于汇集了许多个体的内在属性，通常来自不同的物种，很少与直接测量的肌肉力量进行验证。在这里，我们使用在原位和活体等长、等张和循环收缩过程中记录的大鼠腓肠肌内侧肌力的丰富数据集来测试使用Hill类型肌肉模型预测的力的准确性。我们确定了每个个体的力量长度和力量速度参数，并在模型中使用了这些特定于受试者的固有属性或总体平均属性。体内和原位周期性收缩的模拟力与测量的肌腱力相匹配，R2在0.70到0.86之间，均方根误差(RMSE)在0.10到0.13(归一化到最大等长力)之间。模拟的作用力在最高的运动和循环频率下最不准确，当使用特定于受试者的内在特性时，R2没有显示出改善；然而，RMSE降低了，预测的误差更高。此外，我们还记录和测试了特定于肌肉近端和远端区域的肌肉模型，并将它们与整个肌腹的测量和模型进行了比较：当使用特定解剖区域的数据时，模型性能没有改善。这些结果表明，Hill类型的肌肉模型可以为典型的运动循环收缩产生非常好的性能，当使用特定于受试者的内在特性时，误差略有减少。
Muscle models are commonly based on intrinsic properties pooled across a number of individuals, often from a different species, and rarely validated against directly measured muscle forces. Here we use a rich data set of rat medial gastrocnemius muscle forces recorded during in-situ and in-vivo isometric, isotonic, and cyclic contractions to test the accuracy of forces predicted using Hill-type muscle models. We identified force-length and force-velocity parameters for each individual, and used either these subject-specific intrinsic properties, or population-averaged properties within the models. The modeled forces for cyclic in-vivo and in-situ contractions matched with measured muscle-tendon forces with r2 between 0.70 and 0.86, and root-mean square errors (RMSE) of 0.10 to 0.13 (values normalized to the maximum isometric force). The modeled forces were least accurate at the highest movement and cycle frequencies and did not show an improvement in r2 when subject-specific intrinsic properties were used; however, there was a reduction in the RMSE with fewer predictions having higher errors. We additionally recorded and tested muscle models specific to proximal and distal regions of the muscle and compared them to measures and models from the whole muscle belly: there was no improvement in model performance when using data from specific anatomical regions. These results show that Hill-type muscle models can yield very good performance for cyclic contractions typical of locomotion, with small reductions in errors when subject-specific intrinsic properties are used.
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影响因子：
4.5
作者：
James, RS;Young, IS;Altringham, JD
通讯作者：
Altringham, JD
影响因子：
2.6
作者：
Ahn, A. N.;Konow, N.;Biewener, A. A.
通讯作者：
Biewener, A. A.
DOI：
10.1098/rspb.2013.2914
发表时间：
2014-05-22
影响因子：
4.7
作者：
Azizi, E.
通讯作者：
Azizi, E.
影响因子：
3.3
作者：
Konow, Nicolai;Thexton, Allan;German, Rebecca Z.
通讯作者：
German, Rebecca Z.
影响因子：
2.4
作者：
HERZOG, W;LEONARD, TR;GUIMARAES, ACS
通讯作者：
GUIMARAES, ACS