Digital microfluidic operations on micro-electrode array architecture
Digital microfluidic operations on micro-electrode array architecture
复制标题
微电极阵列架构上的数字微流体操作
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
S. Fan
中科院分区：
文献类型：
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作者：
Gary Wang;D. Teng;S. Fan
随着基于数字微流体的生物芯片获得更多的应用，由于芯片上的多个和并发测定的趋势，其复杂性预计将显着增加。迫切需要提供一种自上而下的设计方法，使生物芯片设计人员能够利用与半导体行业相同水平的计算机辅助设计支持。此外，随着微电子制造技术的规模化和集成器件性能的提高，预计这些微流体生物芯片将与微电子组件集成在下一代系统芯片设计中。本文提出了一种新的电润湿电介质（EWOD）为基础的“微电极阵列架构”，促进了层次化的自顶向下的设计方法的数字微流体的发展路径，也允许微流体和微电子在一个芯片上轻松集成。此外，这种新颖的架构提供了许多优点和灵活性，超过传统的数字微流体，如动态激活的可变大小的电极和动态操纵的多个液滴。
As digital microfluidics-based biochips find more applications, their complexity is expected to increase significantly due to the trend of multiple and concurrent assays on the chip. There is a pressing need to deliver a top-down design methodology that the biochip designer can leverage the same level of computer aided design support as the semiconductor industry now does. Moreover, as microelectronics fabrication technology scaling and integrated device performance improving, it is expected that these microfluidic biochips will be integrated with microelectronic components in next-generation system-on-chip designs. This paper presents a novel electrowetting-on-dielectric (EWOD) based “micro-electrode array architecture” that fosters a development path for hierarchical top-down design approach for digital microfluidics, and also allows easy integration of microfluidics and microelectronics on a single chip. In addition, this novel architecture provides a number of advantages and flexibilities over the conventional digital microfluidics such as dynamic activations of variable-sized electrodes and dynamic manipulations of multiple droplets.