Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment.
Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment.
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DOI：
10.1523/jneurosci.3037-10.2010
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发表时间：
2010-10-27
期刊：
影响因子：
--
通讯作者：
Lu J
中科院分区：
文献类型：
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作者：
Gompf HS;Mathai C;Fuller PM;Wood DA;Pedersen NP;Saper CB;Lu J
蓝斑 (LC) 神经元活动与清醒状态相关，但 LC 损伤仅对日常清醒状态产生微小的改变。在这里，我们报告说，由于暴露于具有新刺激（包括社交互动）的环境，大鼠的 LC 的选择性化学损伤可以防止神经行为和脑电图唤醒的持续升高。当接受特别密集的 LC 神经支配的前扣带皮层 (ACC) 选择性地去除 LC 输入的神经支配或被细胞特异性神经毒素鹅膏蕈酸消除时，会看到类似的结果。顺行追踪结合酪氨酸羟化酶免疫组织化学显示 ACC 末端与 LC 神经元的远端树突并置。我们的数据表明 ACC 既是 LC 的输入源又是其目标之一，并表明这两种结构参与对话，可能为持续注意力提供关键的神经生物学基础。
Locus coeruleus (LC) neuronal activity is correlated with the waking state, yet LC lesions produce only minor alterations in daily wakefulness. Here we report that sustained elevations in neurobehavioral and EEG arousal, in response to exposure to an environment with novel stimuli including social interaction, are prevented by selective chemical lesions of the LC in rats. Similar results are seen when the anterior cingulate cortex (ACC), which receives especially dense LC innervation, is selectively denervated of LC input or is ablated by the cell-specific neurotoxin ibotenic acid. Anterograde tracing combined with tyrosine hydroxyalse immunohistochemistry demonstrates ACC terminals in apposition with the distal dendrites of LC neurons. Our data implicate the ACC as both a source of input to the LC as well as one of its targets and suggests that the two structures engage in a dialog that may provide a critical neurobiological substrate for sustained attention.