Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases
Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases
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DOI：
10.1111/j.1600-0625.2012.01560.x
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发表时间：
2012-10-01
影响因子：
3.6
通讯作者：
Bosserhoff, Anja-Katrin
中科院分区：
文献类型：
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作者：
Schiffner, Susanne;Chen, Suzie;Bosserhoff, Anja-Katrin
小鼠模型系统是研究黑色素瘤发展和转移的未知机制以及开发更有效的治疗方法的关键工具。Tg（Grm 1）EPv黑色素瘤小鼠模型的特征在于在无毛皮肤区域自发发展色素性皮肤黑色素瘤，具有短的潜伏期和100%的潜伏期。在初始分析中描述了局部转移;然而，在远处器官中未观察到黑色素瘤细胞。在这里，我们证明了建立的Tg（Grm 1）EPv黑色素瘤小鼠模型表现出更广泛的转移到远处器官比以前描述的。播散细胞发生表型变化，因为我们观察到大量的非色素Grm 1表达黑色素瘤细胞在远处器官。由于转移过程中的这种变化在人类黑色素瘤中很常见，我们的研究结果表明，这种小鼠模型是研究人类黑色素瘤转移未知机制的一种更有用的工具。
Murine model systems are critically required tools for the investigation of unknown mechanisms of melanoma development and metastasis and for developing more efficient therapies. The Tg(Grm1)EPv melanoma mouse model is characterized by spontaneous development of pigmented cutaneous melanomas at hairless skin regions, with a short latency and 100% penetrance. Local metastasis was described in initial analyses; however, melanoma cells were not observed in distant organs. Here, we demonstrate that the established Tg(Grm1)EPv melanoma mouse model exhibits more extensive metastasis into distant organs than previously described. Disseminated cells undergo phenotypic changes, as we observed high numbers of non-pigmented Grm1-expressing melanoma cells within distant organs. As such changes during metastasis are common in human melanoma, our findings demonstrate that this mouse model represents an even more useful tool to study unknown mechanisms of metastasis in human melanoma than previously assumed.