Creation versus destruction of T cell epitopes in the class II MHC pathway
Creation versus destruction of T cell epitopes in the class II MHC pathway
复制标题
DOI：
10.1111/j.1749-6632.2003.tb06028.x
复制
发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Manoury, B
中科院分区：
文献类型：
--
作者：
Watts, C;Moss, CX;Manoury, B
蛋白酶在 II 类 MHC 抗原加工途径中发挥两个关键作用。他们开始去除 II 类 MHC 的不变链伴侣，并从外源和自身蛋白生成肽，最终捕获并展示给 T 细胞。如何在剧烈的蛋白水解环境中产生合适的肽与它们的完全破坏之间实现平衡尚不清楚。在大多数情况下，也不知道哪些蛋白酶实际上参与了抗原加工。我们最近的研究已确定天冬酰胺内肽酶（AEP 或 legumain）是一种有助于 II 类 MHC 途径中生产性和破坏性抗原加工的酶。正在出现的共识似乎是，单个蛋白水解酶对抗原加工做出了明确且非冗余的贡献。
Proteases perform two key roles in the class II MHC antigen processing pathway. They initiate removal of the invariant chain chaperone for class II MHC and they generate peptides from foreign and self proteins for eventual capture and display to T cells. How a balance is achieved between generation of suitable peptides versus their complete destruction in an aggressive proteolytic environment is not known. Nor is it known in most cases which proteases are actually involved in antigen processing. Our recent studies have identified asparagine endopeptidase (AEP or legumain) as an enzyme that contributes to both productive and destructive antigen processing in the class II MHC pathway. The emerging consensus seems to be that individual proteolytic enzymes make clear and non-redundant contributions to antigen processing.