Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids
Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids
复制标题
对细胞和体液免疫反应的独立影响是果蝇和拟寄生物之间基因型间相互作用的基础
作者：
Alexandre B. Leitão;Xue;Jonathan P Day;S. Pitton;E. Demir;F. Jiggins
群体内宿主抵抗力和寄生虫感染性方面存在丰富的遗传变异是很常见的，感染的结果常常取决于基因型特异性的相互作用。这些效应的背后是复杂的免疫防御，受宿主和寄生虫基因的控制。我们发现果蝇对寄生蜂布拉氏细蜂的免疫反应存在广泛差异。免疫反应的某些方面，例如酚氧化酶活性，主要受宿主基因型的影响。其中一些，例如补体样蛋白 Tep1 的上调，是由寄生虫基因型控制的。其他细胞，例如称为板层细胞的免疫细胞的分化，取决于宿主和寄生虫基因型的特定组合。这些观察结果说明了感染的结果如何取决于对宿主免疫不同方面的独立遗传效应。由于杀灭寄生虫是免疫反应不同成分协同作用的结果，这些观察结果提供了一种生理机制，可以产生诸如上位性和基因型相互作用等现象，这些现象是共同进化模型的基础。
It is common to find abundant genetic variation in host resistance and parasite infectivity within populations, with the outcome of infection frequently depending on genotype-specific interactions. Underlying these effects are complex immune defenses that are under the control of both host and parasite genes. We have found extensive variation in Drosophila melanogaster’s immune response against the parasitoid wasp Leptopilina boulardi. Some aspects of the immune response, such as phenoloxidase activity, are predominantly affected by the host genotype. Some, such as upregulation of the complement-like protein Tep1, are controlled by the parasite genotype. Others, like the differentiation of immune cells called lamellocytes, depend on the specific combination of host and parasite genotypes. These observations illustrate how the outcome of infection depends on independent genetic effects on different aspects of host immunity. As parasite-killing results from the concerted action of different components of the immune response, these observations provide a physiological mechanism to generate phenomena like epistasis and genotype-interactions that underlie models of coevolution.
影响因子：
32.4
作者：
Goulder PJ;Walker BD
通讯作者：
Walker BD
影响因子：
7
作者：
Huang W;Massouras A;Inoue Y;Peiffer J;Ràmia M;Tarone AM;Turlapati L;Zichner T;Zhu D;Lyman RF;Magwire MM;Blankenburg K;Carbone MA;Chang K;Ellis LL;Fernandez S;Han Y;Highnam G;Hjelmen CE;Jack JR;Javaid M;Jayaseelan J;Kalra D;Lee S;Lewis L;Munidasa M;Ongeri F;Patel S;Perales L;Perez A;Pu L;Rollmann SM;Ruth R;Saada N;Warner C;Williams A;Wu YQ;Yamamoto A;Zhang Y;Zhu Y;Anholt RR;Korbel JO;Mittelman D;Muzny DM;Gibbs RA;Barbadilla A;Johnston JS;Stone EA;Richards S;Deplancke B;Mackay TF
通讯作者：
Mackay TF