Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes
Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes
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DOI：
10.1016/s0006-8993(02)03152-9
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发表时间：
2002-09-06
期刊：
影响因子：
2.9
通讯作者：
Swaab, DF
中科院分区：
文献类型：
--
作者：
Dai, JP;Buijs, RM;Swaab, DF
使用一种新的体外死后追踪方法，我们证明了减少轴突运输颞叶皮层神经元相比，在AD患者的前额叶皮层神经元的轴突运输，但不是在非痴呆对照。轴突运输的减少与神经病理改变的程度有关，因为AD时颞叶皮层经历更严重的神经病理改变。本研究首次提供了AD脑中存在轴突运输受损的直接证据。(C)2002 Elsevier Science B.V.保留所有权利。
Using a novel in vitro post mortem tracing method, we demonstrate a decrease of axonal transport in the temporal cortex neurons as compared to axonal transport in the prefrontal cortex neurons in AD patients, but not in non-demented controls. The decrease of axonal transport is related to the degree of neuropathological changes, as the temporal cortex undergoes more severe neuropathological changes in AD. The present study provides, for the first time, direct evidence of the presence of impaired axonal transport in AD brains. (C) 2002 Elsevier Science B.V. All rights reserved.