Low serum sex hormone-binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients
Low serum sex hormone-binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients
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DOI：
10.1111/cen.12360
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发表时间：
2014-06-01
影响因子：
3.2
通讯作者：
Hu, Yun
中科院分区：
文献类型：
--
作者：
Hua, Xiaomin;Sun, Yanjun;Hu, Yun
研究表明，低血清性激素结合球蛋白（SHBG）和睾酮水平与非酒精性脂肪性肝病（NAFLD）有关。然而，目前尚不清楚是否存在关联SHBG和NAFLD之间的独立testosterone.This研究的目的是调查SHBG之间的关系和总的和游离睾酮水平与NAFLD.Subjects和Measures120例NAFLD患者和120例年龄，性别和BMI匹配的非NAFLD患者被纳入病例对照研究。检测血清SHBG、总睾酮（TT）、肝酶、血脂、胰岛素、C肽和血糖。结果NAFLD组血清SHBG水平显著低于非NAFLD组（24中心点5 ± 11中心点0 vs 37中心点6 ± 14中心点4nm，P
IntroductionStudies have indicated that low serum sex hormone-binding globulin (SHBG) and testosterone levels are associated with nonalcoholic fatty liver disease (NAFLD). However, it remains unclear whether an association exists between SHBG and NAFLD independent of testosterone.ObjectiveThis study was aimed to investigate the relationship between SHBG and both total and free testosterone levels with NAFLD.Subjects and MeasuresOne hundred and twenty patients with NAFLD and 120 age-, sex- and BMI-matched patients with non-NAFLD were enrolled into a case-control study. Serums SHBG, total testosterone (TT), liver enzymes, lipids, insulin, C-peptide and plasma glucose were measured. Free testosterone (FT) and fatty liver index were calculated.ResultsSerum SHBG levels were significantly lower in NAFLD group than in non-NAFLD group (24 center dot 5 +/- 11 center dot 0 vs 37 center dot 6 +/- 14 center dot 4 nm, P