The history of the Drosophila TRP channel: the birth of a new channel superfamily.
The history of the Drosophila TRP channel: the birth of a new channel superfamily.
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果蝇TRP通道的历史：新通道超家族的诞生。
DOI：
10.3109/01677063.2010.514369
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发表时间：
2010-12
影响因子：
1.9
通讯作者：
Minke B
中科院分区：
文献类型：
--
作者：
Minke B
瞬时受体电位 (TRP) 通道是参与多种细胞过程的多模式细胞传感器，主要通过改变膜电压和增加细胞 Ca2+ 来实现。这篇综述详细概述了 TRP 家族创始成员果蝇 TRP 通道的历史。该领域始于色氨酸基因的自发突变，该突变在长时间的强光照射下导致失明突变。正是这种突变体使得第一个 TRP 通道的发现成为可能。对果蝇和其他无脊椎动物的电生理学、生化、Ca2+测量以及遗传学研究的结合表明，TRP是一种新型的磷酸肌醇调节的Ca2+渗透通道。 trp 基因的克隆和测序提供了其分子身份。这些开创性的发现导致果蝇 TRP 通道的第一个哺乳动物同源物的分离。我们现在知道 TRP 通道蛋白在进化过程中是保守的，并且存在于大多数生物体、组织和细胞类型中。 TRP通道超家族分为七个相关亚家族：TRPC、TRPM、TRPV、TRPA、TRPP、TRPML和TRPN。目前，人们对 TRP 通道在许多生物过程中的参与有很多了解，包括疼痛的引发、体温调节、唾液分泌、炎症、心血管调节、平滑肌张力、压力调节、Ca2+ 和 Mg2+ 稳态以及溶酶体功能。 TRP 通道超家族的创始成员被发现的天然果蝇感光细胞仍然是研究这一非凡通道基本特征的有用准备。
Transient Receptor Potential (TRP) channels are polymodal cellular sensors involved in a wide variety of cellular processes, mainly by changing membrane voltage and increasing cellular Ca2+. This review outlines in detail the history of the founding member of the TRP family, the Drosophila TRP channel. The field began with a spontaneous mutation in the trp gene that led to a blind mutant during prolonged intense light. It was this mutant that allowed for the discovery of the first TRP channels. A combination of electrophysiological, biochemical, Ca2+ measurements, and genetic studies in flies and in other invertebrates pointed to TRP as a novel phosphoinositide-regulated, and Ca2+ permeable channel. The cloning and sequencing of the trp gene provided its molecular identity. These seminal findings led to the isolation of the first mammalian homologues of the Drosophila TRP channels. We now know that TRP channel proteins are conserved through evolution and are found in most organisms, tissues, and cell-types. The TRP channel superfamily is classified into seven related subfamilies: TRPC, TRPM, TRPV, TRPA, TRPP, TRPML and TRPN. A great deal is known today about participation of TRP channels in many biological processes including initiation of pain, thermoregulation, salivary fluid secretion, inflammation, cardiovascular regulation, smooth muscle tone, pressure regulation, Ca2+ and Mg2+ homeostasis and lysosomal function. The native Drosophila photoreceptor cells, where the founding member of the TRP channels superfamily was found is still a useful preparation to study basic features of this remarkable channel.
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影响因子：
16.2
作者：
Acharya, JK;Jalink, K;Zuker, CS
通讯作者：
Zuker, CS
影响因子：
64.8
作者：
Chyb, S;Raghu, P;Hardie, RC
通讯作者：
Hardie, RC
DOI：
10.1073/pnas.82.20.7116
发表时间：
1985-01-01
影响因子：
11.1
作者：
BLUMENFELD, A;ERUSALIMSKY, J;MINKE, B
通讯作者：
MINKE, B
DOI：
10.1073/pnas.84.19.6939
发表时间：
1987-10-01
影响因子：
11.1
作者：
DEVARY, O;HEICHAL, O;SELINGER, Z
通讯作者：
SELINGER, Z
DOI：
10.1073/pnas.0708368104
发表时间：
2007-11-06
影响因子：
11.1
作者：
Cheng, Yuzhong;Nash, Howard A.
通讯作者：
Nash, Howard A.