Are 24-hour urine samples and creatinine adjustment required for analysis of inorganic arsenic in urine in population studies?
Are 24-hour urine samples and creatinine adjustment required for analysis of inorganic arsenic in urine in population studies?
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DOI：
10.1006/enrs.2002.4339
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发表时间：
2002-03-01
影响因子：
8.3
通讯作者：
Bastone, EB
中科院分区：
文献类型：
--
作者：
Hinwood, AL;Sim, MR;Bastone, EB
在基于人群的研究中，对24小时尿液样本的依从性可能较低，并且为了方便起见，经常收集第一次晨尿样本。尿液中砷浓度的解释受到一系列与暴露无关的因素的影响。为了减少这些因素的影响，常规使用肌酐调整。本研究的目的是确定是否第一次晨尿无机砷浓度接近24小时尿砷浓度和肌酐调整是否改善环境砷浓度和尿无机砷浓度之间的相关性。160个现场样品和相应的24小时尿样收集的人生活在一个范围内的环境砷浓度和无机砷分析，使用硼氢化物胂代原子吸收分光光度法。不同样本类型或是否调整肌酐，尿无机砷浓度之间无显著差异。调整和未调整的样品之间观察到显着的相关性。数据集是高度偏斜的，当只考虑可检测的砷样品时，样品类型之间的关系变得不显着。这项研究的结果表明，现场样本可能足以测量短期接触，使用无机砷作为结果变量，但是，需要更多的工作，更大的数据集。在调查环境暴露的人群研究中，可能不需要对尿无机砷浓度进行肌酐校正。(C)2002 Elsevier Science（美国）。
Compliance with 24-h urine samples can be low in population-based studies and first morning void urine samples are often collected for convenience. Interpretation of arsenic concentrations in urine is influenced by a range of factors unrelated to exposure. To reduce the influence of such factors, creatinine adjustment is routinely used. This study aimed to determine whether first morning void urinary inorganic arsenic concentrations approximate 24-h urinary arsenic concentrations and whether creatinine adjustment improved the correlation between environmental arsenic concentrations and urinary inorganic arsenic concentrations. One hundred sixty spot samples and corresponding 24-h urine samples were collected from people living in areas with a range of environmental arsenic concentrations and analyzed for inorganic arsenic using borohydride arsine generation followed by atomic absorption spectrophotometry. There were no significant differences between the urinary inorganic arsenic concentrations for the different sample types or whether creatinine adjusted or not. Significant correlations were observed between adjusted and unadjusted samples. The data set was highly skewed and when only detectable arsenic samples were considered, the relationship between sample types became nonsignificant. The results of this study suggest that spot samples may be adequate for measuring short-term exposure, using inorganic arsenic as the outcome variable; however, additional work on a larger data set is required. Creatinine adjustment of urinary inorganic arsenic concentrations may not be required in population studies investigating environmental exposure. (C) 2002 Elsevier Science (USA).