Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment.
Hormonal responses to meta-chlorophenylpiperazine (m-CPP) are undiminished by acute m-CPP pretreatment.
复制标题
急性 m-CPP 预处理不会减弱对间氯苯基哌嗪 (m-CPP) 的激素反应。
DOI：
10.1016/0165-1781(96)02826-0
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发表时间：
1996
影响因子：
11.3
通讯作者：
Siever,LJ
中科院分区：
文献类型：
--
作者：
Coccaro,EF;Kavoussi,RJ;Trestman,RL;Gabriel,SM;Cooper,TB;Siever,LJ
用间氯苯基哌嗪（m-CPP，0.5 mg/kg，p.o.）在健康志愿者中进行，以测试激素反应的短期稳定性。以相同的方式进行攻击，并在连续几天进行。循环m-CPP血浆水平以及对m-CPP的催乳素和皮质醇反应在2天内的幅度相应相似。这些数据表明，催乳素和皮质醇对单次口服m-CPP的反应至少在24小时内保持稳定。
Two challenges with meta-chlorophenylpiperazine (m-CPP, 0.5 mg/kg, p.o.) were performed in healthy volunteers to test the short-term stability of hormonal responses. Challenges were performed in an identical fashion and were conducted on sequential days. Circulating m-CPP plasma levels, as well as prolactin and cortisol responses to m-CPP, were correspondingly similar in magnitude on the 2 days. These data suggest that both prolactin and cortisol responses to single oral administrations of m-CPP are stable over at least a 24-h period.