Age related changes in intraocular pressure in a large Japanese population -: A cross-sectional and longitudinal study
Age related changes in intraocular pressure in a large Japanese population -: A cross-sectional and longitudinal study
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DOI：
10.1016/s0161-6420(99)90417-7
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发表时间：
1999-10-01
期刊：
影响因子：
13.7
通讯作者：
Kuzuya, F
中科院分区：
文献类型：
--
作者：
Nomura, H;Shimokata, H;Kuzuya, F
目的：为了评估年龄、血压和体重指数（BMI）对日本大规模人群眼内压（IOP）的影响，设计：横断面和纵向研究。参与者：本研究的参与者为69，643名日本男性和女性，年龄在20至79岁之间。他们是办公室职员及其家人，曾于一九八九至一九九七年期间每年接受健康检查。回顾性审查了接受健康检查的参与者的记录。每个参与者都根据标准协议进行检查，包括使用非接触式眼压计进行眼压测量，人体测量和血压测量。对受试者最近一次访视的数据进行了横断面分析。对20世纪20年代至60年代出生的68，998名男性和女性参与者的数据进行纵向分析。测试：眼压测量和人体测量。主要结果测量：确定IOP、收缩压、舒张压和BMI的平均值。采用多元线性回归模型结合横断面分析研究年龄、收缩压、舒张压和BMI与眼压的关系。在纵向分析中，使用混合效应模型计算IOP对年龄、收缩压、舒张压和BMI的回归系数。结果：男性和女性的平均（+/-标准差）IOP值分别为11.9 +/- 2.5和11.5 +/- 2.4 mmHg。横断面分析显示，随着年龄的增长，眼压显著降低（P < 0.001）。纵向分析显示，无论男女，眼压均随年龄增长而显著升高（P < 0.001）。SYSTEMS血压和BMI呈正相关，IOP的横截面和纵向studies.Conclusion：作者发现了一个不一致的变化，在IOP对年龄之间的横截面和纵向分析。怀疑出生队列的眼部特征差异影响日本人群的IOP。
Objective: To assess the influence of aging, blood pressure, and body mass index (BMI) on intraocular pressure (IOP) in a large Japanese population.Design: Cross-sectional and longitudinal study.Participants: The participants in this study were 69,643 Japanese men and women 20 to 79 years of age. They were office workers and their family members who had received annual health examinations from 1989 to 1997. The records of the participants who received health examinations were reviewed retrospectively. Each participant was examined according to a standard protocol, including tonometry with a noncontact tonometer, anthropometric measurements, and blood pressure measurements. The data from the subjects' most recent visit were analyzed cross-sectionally. The data from the 68,998 men and women of the total participants who were bom between the 1920s and 1960s were used in longitudinal analysis.Testing: Tonometric and anthropometric measurements.Main Outcome Measures: Mean values of IOP, systolic blood pressure, diastolic blood pressure, and BMI were determined. The relationship among IOP, age, systolic blood pressure, diastolic blood pressure, and BMI was studied using the multiple linear regression model with cross-sectional analysis. In longitudinal analysis, regression coefficients of IOP against age, systolic blood pressure, diastolic blood pressure, and BMI were calculated using the mixed effect model.Results: The mean (+/- standard deviation) IOP values for men and women were 11.9 +/- 2.5 and 11.5 +/- 2.4 mmHg, respectively. In cross-sectional analysis, IOP decreased significantly with age (P < 0.001). However, longitudinal analysis showed that IOP increased significantly with age in both men and women (P < 0.001). Systolic blood pressure and BMI were positively correlated to IOP in both the cross-sectional and longitudinal studies.Conclusion: The authors found an inconsistency in the change in IOP against age between cross-sectional and longitudinal analysis. It is suspected that birth cohort differences in ocular characteristics influence IOP in the Japanese population.