Accelerating joint relaxation-diffusion MRI by integrating time division multiplexing and simultaneous multi-slice (TDM-SMS) strategies.
Accelerating joint relaxation-diffusion MRI by integrating time division multiplexing and simultaneous multi-slice (TDM-SMS) strategies.
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DOI：
10.1002/mrm.29160
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发表时间：
2022-06
影响因子：
3.3
通讯作者：
Ning, Lipeng
中科院分区：
文献类型：
--
作者：
Ji, Yang;Hoge, W. Scott;Gagoski, Borjan;Westin, Carl-Fredrik;Rathi, Yogesh;Ning, Lipeng
通过将时分多路传输(TDM)和同步多层(SMS)相结合用于回波平面成像(EPI)，加速松弛-扩散成像的获取，并评估成像质量和扩散措施。将时分复用(TDM)技术和同时多层(SMS)方法相结合，以获得高的层加速系数(例如6倍)以获得松弛扩散磁共振成像。开发了该序列的两个变体，称为TDM3e-Sms和TDM2s-Sms，以分别同时获得具有3个不同回波时间(TES)的片组和具有相同TE的2个片组。这两个序列在3T扫描仪上与活体人脑进行了评估，并与标准的单频段(SB)-EPI和SMS-EPI进行了扩散测量和声道成像结果的比较。实验结果表明，与MB=2的标准SMS-EPI相比，总层厚加速度为6(MP=3×MB=2)的TDM3e-SMS序列提供了相似的图像强度和微观结构测量，而与MB=4的标准SMS-EPI相比，TDM3e-SMS序列的强度偏差更小。三种序列的回声时间(TE)与平均峰度(MK)呈相似的正相关，TE与白质的平均弥散系数(MD)呈负相关。多纤维纤维束成像还显示了不同序列之间TE相关测量结果的一致性。TDM2S-SMS序列(MP=2，MB=2)也提供与用于单TE扩散成像的标准SMS-EPI序列(MB=2)相似的成像措施。TDM-SMS序列可以在不降低成像质量的情况下为SMS提供额外的2倍到3倍的加速。随着扫描时间的显著减少，TDM-SMS使关节松弛-扩散磁共振成像成为神经影像研究中一种可行的技术，用于研究大脑疾病的新标记物。
To accelerate the acquisition of relaxation-diffusion imaging by integrating time-division multiplexing (TDM) with simultaneous multi-slice (SMS) for echo-planar imaging (EPI) and evaluate imaging quality and diffusion measures. The time-division multiplexing (TDM) technique and simultaneous multi-slice (SMS) method were integrated to achieve a high slice-acceleration (e.g., 6x) factor for acquiring relaxation-diffusion MRI. Two variants of the sequence, referred to as TDM3e-SMS and TDM2s-SMS, were developed to simultaneously acquire slice groups with 3 distinct echo times (TEs) and 2 slice groups with the same TE, respectively. Both sequences were evaluated on a 3T scanner with in vivo human brains and compared with standard single-band (SB) -EPI and SMS-EPI using diffusion measures and tractography results. Experimental results showed that the TDM3e-SMS sequence with total slice acceleration of 6 (multiplexing factor (MP) = 3 x multi-band factor (MB) =2) provided similar image intensity and microstructure measures compared to standard SMS-EPI with MB=2, and yielded less bias in intensity compared to standard SMS-EPI with MB=4. The three sequences showed a similar positive correlation between echo time (TE) and mean kurtosis (MK) and a negative correlation between TE and mean diffusivity (MD) in white matter. Multi-fiber tractography also shows consistency of results in TE-dependent measures between different sequences. The TDM2s-SMS sequence (MP=2, MB=2) also provided similar imaging measures as standard SMS-EPI sequence (MB=2) for single-TE diffusion imaging. The TDM-SMS sequence can provide additional 2x to 3x acceleration to SMS without degrading imaging quality. With the significant reduction in scan time, TDM-SMS makes joint relaxation-diffusion MRI a feasible technique in neuroimaging research to investigate new markers of brain disorders.
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影响因子：
5.7
作者：
Barakovic M;Tax CMW;Rudrapatna U;Chamberland M;Rafael-Patino J;Granziera C;Thiran JP;Daducci A;Canales-Rodríguez EJ;Jones DK
通讯作者：
Jones DK
影响因子：
2.2
作者：
Hürlimann, MD;Venkataramanan, L
通讯作者：
Venkataramanan, L
影响因子：
8.3
作者：
Cheung JS;Wang E;Lo EH;Sun PZ
通讯作者：
Sun PZ
影响因子：
3.3
作者：
Barth M;Breuer F;Koopmans PJ;Norris DG;Poser BA
通讯作者：
Poser BA
DOI：
10.1111/jon.12708
发表时间：
2020-05
期刊：
Journal of neuroimaging : official journal of the American Society of Neuroimaging
影响因子：
--
作者：
Afacan O;Hoge WS;Wallace TE;Gholipour A;Kurugol S;Warfield SK
通讯作者：
Warfield SK