Immune complex injury of the lung.
Immune complex injury of the lung.
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肺部免疫复合物损伤。
DOI：
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发表时间：
1979
影响因子：
6
通讯作者：
R. Dreisin
中科院分区：
文献类型：
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作者：
Ronald P. Daniele;Peter M. Henson;J. Fantone;P. A. Ward;R. Dreisin
目前存在大量证据表明免疫复合物在肺部炎性疾病中起重要作用。在临床上，特发性肺纤维化、肺嗜酸性肉芽肿和系统性红斑狼疮已被证明与肺和血清中免疫复合物的存在有关。在实验上，有令人信服的证据表明，急性肺损伤可以由复合物在血管壁中的沉积或由滴注到气道中的免疫复合物的存在触发。正如预期的那样，观察到的反应是补体和嗜中性粒细胞依赖性的。由补体激活产物（C5a和相关肽）引起的肺中的形态学变化取决于补体激活是发生在脉管系统内还是发生在气道内。气道激活与肺泡内中性粒细胞积聚有关，而血管内激活导致毛细血管内中性粒细胞隔离。血管系统内免疫复合物的慢性形成（在“慢性血清病”模型中）导致间质纤维化反应和基底膜增厚。最近的研究血管内输注预制的免疫复合物表明，某些类型的复合物定位在肺内的倾向。这些"趋肺"复合物与非趋肺复合物的区别仅在于抗原与抗体的比例。补体似乎不改变某些复合物在肺内定位的趋势。这些研究强调了免疫复合物在肺损伤中的潜在重要性，并指出了参与定位过程和损伤过程的各种机制。
Abundant evidence currently exists to suggest that immune complexes play an important role in inflammatory diseases of the lung. Clinically, idiopathic pulmonary fibrosis, eosinophilic granuloma of lung, and systemic lupus erythematosus have been shown to be associated with the presence of immune complexes both in lung and in the serum. Experimentally, there is compelling evidence that acute lung injury can be triggered by the deposition of complexes in vascular walls or by the presence of performed immune complexes instilled into the airways. The observed reactions are, as expected, complement- and neutrophil-dependent. The morphologic changes in lung caused by products of complement activation (C5a and related peptides) depend on whether complement activation occurs within the vasculature or within the airways. Airway activation is associated with intraalveolar accumulations of neutrophils, while intravascular activation leads to intracapillary sequestration of neutrophils. The chronic formation of immune complexes within the vasculature (in the model of "chronic serum sickness") leads to an interstitial fibrotic reaction and a thickening of basement membranes. Recent studies of intravascularly infused preformed immune complexes indicate a proclivity for certain types of complexes to localize within lung. These "lung-seeking" complexes differ from non-lung-seeking complexes only in the ratio of antigen to antibody. Complement does not seem to alter the tendancy for certain complexes to localize within lung. These studies emphasize the potential importance of immune complexes in lung injury and point out the variety of mechanisms involved in both the localization process and the injury process.