Gender and age modify the association between APOE and AD-related neuropathology
Gender and age modify the association between APOE and AD-related neuropathology
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DOI：
10.1212/wnl.56.12.1696
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发表时间：
2001-06-26
期刊：
影响因子：
9.9
通讯作者：
Braak, H
中科院分区：
文献类型：
--
作者：
Ghebremedhin, E;Schultz, C;Braak, H
目的：探讨载脂蛋白E（APOE）基因多态性对AD相关神经元缠结（NFT）和老年斑（SP）形成的影响。方法：对729例（男359例，女370例;年龄60 ~ 99岁）常规尸检脑标本进行了调查。所有的大脑进行分类神经病理学根据程序允许分化的六个NFT阶段和三个SP阶段。对所有病例进行APOE基因分型。结果：APOE ε 4等位基因不仅与SP相关（p < 0.0001），而且与NFT形成相关（p < 0.0001）。ε 4等位基因对NFT形成的影响在大于或等于80岁时被注意到（p < 0.0001），但在60岁和79岁之间没有（p = 0.12）。在60 - 79岁的女性中发现了4等位基因与SP之间的关联（p < 0.0001），但在80岁时没有发现（p = 0.063）。相比之下，男性在两个年龄组中都表现出相关性（p = 0.001和p = 0.001）。结论：结果证实了ε 4等位基因与AD相关病变的两种类型之间的关联，并表明这种关联因年龄和性别而不同。
Objective: To assess the impact of apolipoprotein E (APOE) polymorphism on AD-related neurofibrillary tangle (NFT) formation and senile plaques (SP). Methods: A sample of 729 routine autopsy brains (359 men, 370 women; age range, 60 to 99 years) was investigated. All brains were classified neuropathologically according to a procedure permitting differentiation of six NFT stages and three SP stages. APOE genotyping was performed on all cases. Results: The epsilon4 allele of APOE was associated not only with SP (p < 0.0001) but also with NFT formation (p < 0.0001). The effect of the epsilon4 allele on NFT formation was noted at ages greater than or equal to 80 years (p < 0.0001) but not between ages 60 and 79 years (p = 0.12). An association between the 4 allele and SP for women was found at ages 60 to 79 years (p < 0.0001) but not at 80 years of age (p = 0.063). By comparison, men showed an association in both age categories (p = 0.001 and p = 0.001). Conclusion: The results confirm the association between the epsilon4 allele and both typos of AD-related lesions and show that this association is differentially modified by age and gender.