Vaspin and visfatin/Nampt are interesting interrelated adipokines playing a role in the pathogenesis of type 2 diabetes mellitus
Vaspin and visfatin/Nampt are interesting interrelated adipokines playing a role in the pathogenesis of type 2 diabetes mellitus
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DOI：
10.1016/j.metabol.2010.04.008
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发表时间：
2011-01-01
影响因子：
9.8
通讯作者：
Amin, Ashraf I.
中科院分区：
文献类型：
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作者：
El-Mesallamy, Hala O.;Kassem, Dina H.;Amin, Ashraf I.
最近，vaspin和visfatin/Nampt已被鉴定为分别具有胰岛素增敏和胰岛素模拟作用的有趣的新型脂肪因子，然而它们之间的关系尚未阐明，并且它们在2型糖尿病（T2 DM）中的循环水平尚未得到充分研究。本研究旨在调查埃及2型糖尿病患者的脂肪因子水平是否发生改变，并研究这些新型脂肪因子相互之间以及与胰岛素之间的相关性抵抗、白细胞介素-6（IL-6）和其它生化参数在非肥胖和肥胖T2 DM患者以及匹配的健康非糖尿病对照受试者中测量vaspin、visfatin/Nampt、IL-6、胰岛素和其它参数的水平。通过酶联免疫吸附测定法测量vaspin、visfatin/Nampt和IL-6水平，而用化学发光技术测定胰岛素水平，发现非肥胖者Vaspin和visfatin/Nampt水平显著升高，（分别为1.62 ± 0.22和25.9 ± 3.44 ng/mL）和肥胖T2 DM患者（分别为2 76 ± 0 38和45 4 ± 4 60 ng/mL）与对照组相比（分别为0.42 ± 0.05和9.37 ± 1.98ng/mL），P <0.01。此外，vaspin和visfatin/Nampt水平相互之间以及与其他生化指标之间均呈显著正相关。vaspin和visfatin/Nampt可能在T2 DM的发病机制中起重要作用。此外，vaspin，visfatin/Nampt，vaspin与IL 6之间存在显著的相关性，除了抑制未知的IL 6外，还应考虑vaspin的其他可能的作用机制。底物蛋白酶（C）2011 Elsevier Inc版权所有
Recently vaspin and visfatin/Nampt have been identified as interesting novel adipokines having insulin-sensitizing and insulin-mimetic effects, respectively However the relationship between them has not been elucidated, and their circulating levels in type 2 diabetes mellitus (T2DM) have not been adequately studied Therefore, this study was designed to investigate whether their levels are altered in Egyptian T2DM patients and to study the correlation of these novel adipokines with each other and with insulin resistance, interleukin-6 (IL 6), and other biochemical parameters The levels of vaspin, visfatin/Nampt, IL-6, insulin, and other parameters were measured in nonobese and obese T2DM patients together with matched healthy nondiabetic control subjects Vaspin, visfatin/Nampt and 1L-6 levels were measured by enzyme-linked immunosorbent assay, whereas insulin levels were measured by chemiluminescence technique Vaspin and visfatin/Nampt levels were found to be significantly elevated in nonobese (1 62 +/- 0 22 and 25 9 +/- 3 44 ng/mL, respectively) and obese T2DM patients (2 76 +/- 0 38 and 45 4 +/- 4 60 ng/mL, respectively) compared with control subjects (0 42 +/- 0 05 and 9 37 +/- 1 98 ng/mL, respectively) at P < 01 In addition, vaspin and visfatin/Nampt levels were found to be significantly positively correlated with each other and with other biochemical parameters In conclusion, both vaspin and visfatin/Nampt might play an important role m the pathogenesis of T2DM In addition, the 3 adipokines vaspin, visfatin/Nampt, and IL 6 are significantly interrelated with each other Other possible mechanisms of action for vaspin should be considered besides the inhibition of unknown substrate proteases (C) 2011 Elsevier Inc All rights reserved