Prostate-specific and androgen-dependent expression of a novel homeobox gene
Prostate-specific and androgen-dependent expression of a novel homeobox gene
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DOI：
10.1074/jbc.271.50.31779
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发表时间：
1996-12-13
影响因子：
4.8
通讯作者：
Jay, G
中科院分区：
文献类型：
--
作者：
Bieberich, CJ;Fujita, K;Jay, G
在小鼠NK家族中发现了一个与果蝇NK-3同源盒基因相关的新成员，命名为Nkx-3.1，该基因在成年动物的前列腺中表达，去势后Nkx-3.1 mRNA水平显著下降，表明其表达是雄激素依赖性的。原位杂交结果表明，Nkx-3.1在前列腺中的表达局限于上皮细胞，新生儿尿道上皮细胞中检测到Nkx-3.1 mRNA，该上皮细胞被周围间充质诱导内陷形成前列腺芽。总之，这些观察结果表明，Nkx-3.1蛋白，它可能作为一个转录因子的功能，在启动前列腺发育和前列腺上皮细胞的分化状态的维持中起着突出的作用。
A new member of the mouse NK family of homeobox genes that is related to Drosophila NK-3 has been identified, Expression of this gene, termed Nkx-3.1, is largely restricted to the prostate gland in adult animals, The level of Nkx-3.1 mRNA decreases markedly in response to castration, suggesting that its expression is androgen-dependent. In situ hybridization analyses demonstrated that expression of Nkx-3.1 in the prostate is confined to epithelial cells, In newborns, Nkx-3.1 mRNA is detected in the urethral epithelium that is being induced by the surrounding mesenchyme to invaginate to form prostatic buds. Together, these observations suggest that the Nkx-3.1 protein, which likely functions as a transcription factor, plays a prominent role both in the initiation of prostate development and in the maintenance of the differentiated state of prostatic epithelial cells.