A Model for Selecting One of Two Medical Treatments
A Model for Selecting One of Two Medical Treatments
复制标题
选择两种治疗方法之一的模型
DOI：
10.1080/01621459.1963.10500853
复制
发表时间：
1963
影响因子：
3.7
通讯作者：
T. Colton
中科院分区：
文献类型：
--
作者：
T. Colton
摘要提出了一种简单的成本函数方法，用于设计一个最优的临床试验，当一种疾病的总共N个病人要用两种药物治疗之一时。成本函数仅用一个成本来构建，即用两种治疗方法中的上级或下级治疗患者的后果。考虑固定样本量和序贯试验。极大极小、极大极小和贝叶斯方法用于确定固定样本试验的最优规模和序贯试验边界的最优位置。不同的方法的比较，以及固定和顺序计划的结果的比较。
Abstract A simple cost function approach is proposed for designing an optimal clinical trial when a total of N patients with a disease are to be treated with one of two medical treatments. The cost function is constructed with but one cost, the consequences of treating a patient with the superior or inferior of the two treatments. Fixed sample size and sequential trials are considered. Minimax, maximin, and Bayesian approaches are used for determining the optimal size of a fixed sample trial and the optimal position of the boundaries of a sequential trial. Comparisons of the different approaches are made as well as comparisons of the results for the fixed and sequential plans.