Aluminum contamination of neonatal parenteral nutrient solutions and additives.
Aluminum contamination of neonatal parenteral nutrient solutions and additives.
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新生儿肠外营养液和添加剂的铝污染。
DOI：
10.1093/ajhp/55.10.1071
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
V. Herson
中科院分区：
文献类型：
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作者：
J. F. Mouser;A. Wu;V. Herson
已发现罗格列酮在临床上不与对乙酰氨基酚、磺酰脲类、地高辛或华法林相互作用或改变其药代动力学。1然而，胆汁酸螯合剂如考来烯胺可使曲格列酮的吸收减少约70%。已发现曲格列酮可使口服避孕药和特非那定的血浆浓度分别降低30%和50- 70%，推测是通过与细胞色素P-450 3A 4代谢途径竞争。此外，大约99%的循环曲格列酮与血浆蛋白结合，因此可以从蛋白质中置换其他药物。1尚未发表曲格列酮与华法林之间相互作用的报告。这封信描述了曲格列酮明显增强华法林对国际标准化比值（INR）的影响。一名51岁的男性于1997年8月入院接受重复股腘动脉旁路移植术;该手术于1997年1月首次进行。他在1979年接受了机械主动脉瓣，并服用华法林预防血栓栓塞。在过去的7个月里，他的INR一直稳定在2.4和3.3之间（目标，2.5-3.5），他的华法林钠每日剂量的每周总剂量为45 mg。患者有重度外周血管疾病（伴短暂性脑缺血发作）、糖尿病、高血压和抑郁症病史。
roglitazone has been found not to interact clinically with or alter the pharmacokinetics of acetaminophen, sulfonylureas, digoxin, or warfarin. 1 However, bile acid sequestrants such as cholestyramine may decrease the absorption of troglitazone by about 70%. Troglitazone has been found to decrease the plasma concentrations of oral contraceptives and terfenadine by 30% and 50–70%, respectively, presumably by competing with the cytochrome P-450 3A4 metabolic pathway. Also, approximately 99% of circulating troglitazone is bound to plasma proteins and thus may displace other drugs from the proteins. 1 There have been no published reports of an interaction between troglitazone and warfarin. This letter describes troglitazone apparently potentiating the effect of warfarin on the International Normalized Ratio (INR). A 51-year-old man was admitted to the hospital in August 1997 for repeat femoral–popliteal arterial bypass grafting; the procedure had first been performed in January 1997. He had received a mechanical aortic valve in 1979 and was taking warfarin to prevent thromboembolism. During the previous seven months, his INR had been stable at between 2.4 and 3.3 (goal, 2.5–3.5), and the weekly total of his daily warfarin sodium doses had been 45 mg. He had a history of severe peripheral vascular disease (with a transient ischemic attack), diabetes mellitus, hypertension, and depression.