Synthesis and NMR spectroscopic investigations with 3-amino-, 3-hydroxy-, and 3-methoxy-4-acyl-1-phenyl-2-pyrazolin-5-ones
Synthesis and NMR spectroscopic investigations with 3-amino-, 3-hydroxy-, and 3-methoxy-4-acyl-1-phenyl-2-pyrazolin-5-ones
复制标题
DOI：
10.3987/com-04-10046
复制
发表时间：
2004-06-01
期刊：
影响因子：
0.6
通讯作者：
Hallak, L
中科院分区：
文献类型：
--
作者：
Holzer, W;Hallak, L
在1，4-二氧六环中，3-氨基-、3-羟基-和3-甲氧基-1-苯基-2-吡唑啉-5-酮与羧酰氯/氢氧化钙反应，主要得到相应的4-酰基-2-吡唑啉-5-酮。3-甲氧基-1-苯基-2-吡唑啉-5-酮与二甲基甲酰胺二乙缩醛反应得到4-二甲氨基亚甲基产物的（E）/（Z）-混合物，与四氰基乙烯反应得到4-二氰基亚甲基产物，而与亚硝酸反应得到4-羟肟基衍生物。NMR-光谱研究（H-1，C-13，N-15）与所获得的反应产物。
Reaction of 3-amino-, 3-hydroxy- and 3-methoxy-1-phenyl-2-pyrazolin-5-one with carboxylic acid chlorides/calcium hydroxide in 1,4-dioxane mainly affords the corresponding 4-acyl-2-pyrazolin-5-ones. 3-Methoxy-1-phenyl-2-pyrazolin-5-one reacts with dimethylformamide diethyl acetal to give an (E)/(Z)-mixture of the 4-dimethylaminomethylene product, with tetracyanoethylene the 4-dicyanomethylene product is obtained, whereas with nitrous acid the 4-hydroximino derivative results. NMR-spectroscopic investigations (H-1, C-13, N-15) with the obtained reaction products are presented.