Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: a longitudinal twin study.
Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: a longitudinal twin study.
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DOI：
10.1017/s0954579409990186
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发表时间：
2009
影响因子：
3.3
通讯作者：
McGue M
中科院分区：
文献类型：
--
作者：
Bornovalova MA;Hicks BM;Iacono WG;McGue M
虽然人格障碍在终生发展的背景下得到了最好的理解，但研究其纵向轨迹的工作却很少。了解预期病程以及遗传和环境因素对这些疾病的影响，对于详细了解导致这些疾病表现的风险过程是必要的。目前的研究考察了从青春期(14岁)到成年(24岁)的10年时间里，交界性人格障碍(BPD)的纵向病程和遗传率。在这样做的过程中，我们通过使用大量青春期女性双胞胎的社区样本、BPD特征的敏感维度测量、延长的随访期和纵向双胞胎设计来建立现有研究，该设计允许我们调查从青春期中期到成年早期的四个离散年龄BPD特征的遗传力。结果表明，从青春期到成年期，平均水平的BPD特征显着下降，但等级顺序稳定性保持较高。BPD性状在所有年龄段都是中等可遗传性的，从14岁到24岁有轻微的遗传力增加的趋势。遗传信息潜在生长曲线模型表明，BPD性状的稳定性和变化性受遗传因素的影响较大，受非共有环境因素的影响较小。我们的结果表明，与其他人格维度一样，特质BPD随着个体从青春期到成年期的成熟而下降，这一过程部分受到影响BPD特质稳定性的相同遗传因素的影响。
Although personality disorders are best understood in the context of lifetime development, there is a paucity of work examining their longitudinal trajectory. An understanding of the expected course and the genetic and environmental contributions to these disorders is necessary for a detailed understanding of risk processes that lead to their manifestation. The current study examined the longitudinal course and heritability of borderline personality disorder (BPD) over a period of 10 years starting in adolescence (age 14) and ending in adulthood (age 24). In doing so, we built on existing research by using a large community sample of adolescent female twins, a sensitive dimensional measure of BPD traits, an extended follow-up period, and a longitudinal twin design that allowed us to investigate the heritability of BPD traits at four discrete ages spanning mid-adolescence to early adulthood. Results indicated that mean-level BPD traits significantly decline from adolescence to adulthood but rank order stability remained high. BPD traits were moderately heritable at all ages with a slight trend for increased heritability from age 14 to age 24. A genetically-informed latent growth curve model indicated that both the stability and change of BPD traits are highly influenced by genetic factors and modestly by non-shared environmental factors. Our results indicate that as is the case for other personality dimensions, trait BPD declines as individuals mature from adolescence to adulthood and that this process is influenced in part by the same genetic factors that influence BPD trait stability.