Thought-Controlled Nanoscale Robots in a Living Host.
Thought-Controlled Nanoscale Robots in a Living Host.
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DOI：
10.1371/journal.pone.0161227
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Bachelet I
中科院分区：
文献类型：
--
作者：
Arnon S;Dahan N;Koren A;Radiano O;Ronen M;Yannay T;Giron J;Ben-Ami L;Amir Y;Hel-Or Y;Friedman D;Bachelet I
我们报告了一种新型脑机接口，使人类操作员能够通过大脑活动控制活体动物体内的纳米级机器人。记录的脑电图模式由算法在线识别，进而控制电磁场的状态。该场会引起数十亿个与金属纳米颗粒相连的机械驱动 DNA 折纸机器人的局部加热，导致它们可逆激活并随后暴露生物活性有效载荷。作为原理证明，我们展示了 DNA 机器人的激活，通过一项认知紧张任务，在昆虫 Blaberus disoidalis 体内引起细胞效应。该技术能够根据受试者的认知状态在线打开和关闭生物活性分子，这对精神分裂症、抑郁症和注意力缺陷等疾病的治疗控制具有潜在影响，这些疾病是诊断和治疗最具挑战性的疾病之一。
We report a new type of brain-machine interface enabling a human operator to control nanometer-size robots inside a living animal by brain activity. Recorded EEG patterns are recognized online by an algorithm, which in turn controls the state of an electromagnetic field. The field induces the local heating of billions of mechanically-actuating DNA origami robots tethered to metal nanoparticles, leading to their reversible activation and subsequent exposure of a bioactive payload. As a proof of principle we demonstrate activation of DNA robots to cause a cellular effect inside the insect Blaberus discoidalis, by a cognitively straining task. This technology enables the online switching of a bioactive molecule on and off in response to a subject’s cognitive state, with potential implications to therapeutic control in disorders such as schizophrenia, depression, and attention deficits, which are among the most challenging conditions to diagnose and treat.