Amygdala Functional Connectivity During Self-Face Processing in Depressed Adolescents With Recent Suicide Attempt
Amygdala Functional Connectivity During Self-Face Processing in Depressed Adolescents With Recent Suicide Attempt
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DOI：
10.1016/j.jaac.2018.06.036
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发表时间：
2019-02-01
影响因子：
13.3
通讯作者：
Quevedo, Karina
中科院分区：
文献类型：
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作者：
Alarcon, Gabriela;Sauder, Mitchell;Quevedo, Karina
目的：自杀是青少年死亡的第二大原因，然而，缺乏自杀风险的客观生物标志物。异常的自我面孔杏仁核活动与自杀意念及其与自我处理神经区域的连接有关（如内侧前额叶皮质）可能是自杀的危险因素。（年龄11-17岁; N = 120）分为四组：健康对照组（HC）、自杀意念低的抑郁症个体（LS）、自杀意念高的抑郁症个体（HS）和自杀意念高的抑郁症个体（SA）。青少年在扫描仪中完成了情绪（快乐、悲伤、中性）的自我面孔识别任务。双侧杏仁核任务依赖的功能连接与心理生理相互作用分析。研究人员比较了不同群体之间的连通性，以及不同情绪和大脑半球之间的自我与他人面孔之间的连通性。体素结果进行阈值化（p < .005，未校正）和校正的多重比较（p < .05，familywise error）。结果：HS和SA显示更大的杏仁核连接与背外侧前额叶皮层，背内侧前额叶皮层，和楔前叶，相比LS，谁，反过来，表现出更大的连接比HC。更大的左杏仁核喙前扣带皮层（rACC）的连接，观察SA相比，所有其他组，而右杏仁核rACC的连接更大的HS与LS和HC。结论：杏仁核和其他区域之间的连接更大，涉及在自我面对处理区分自杀意念和自杀企图组。剂量依赖性反应表明，在自我面孔处理过程中，更大的rACC-左杏仁核连接与最近的自杀企图有关，但更大的rACC-右杏仁核连接与自杀意念有关。
Objective: Suicide is the second leading cause of death among adolescents; however, objective biomarkers of suicide risk are lacking. Aberrant self-face amygdala activity is associated with suicide ideation, and its connectivity with neural regions that enable self-processing (eg medial prefrontal cortex) may be a suicide risk factor.Method: Adolescents (aged 11-17 years; N = 120) were sorted into four groups: healthy controls (HC), depressed individuals with low suicide ideation (LS), depressed individuals with high suicide ideation (HS), and depressed suicide attempters (SA). Youth completed an emotional (Happy, Sad, Neutral) self-face recognition task in the scanner. Bilateral amygdala task-dependent functional connectivity was determined with psychophysiological interaction analysis. Connectivity was compared across groups and within Self versus Other faces across emotions and hemispheres. Voxelwise results were thresholded (p < .005, uncorrected) and corrected for multiple comparisons (p < .05, familywise error).Results: Both HS and SA displayed greater amygdala connectivity with the dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and pre-cuneus, compared to LS, who, in turn, showed greater connectivity than HC. Greater left amygdala-rostral anterior cingulate cortex (rACC) connectivity was observed in SA compared to all other groups, whereas right amygdala-rACC connectivity was greater in HS versus LS and HC.Conclusion: Greater connectivity between amygdala and other regions implicated in self-face processing differentiated suicide ideation and suicide attempt groups. A dose-dependent response showed that greater rACC-left amygdala connectivity during self-face processing was associated with a recent suicide attempt, but that a greater rACC-right amygdala connectivity was associated with suicide ideation.