Gill developmental program in the teleost mandibular arch.
Gill developmental program in the teleost mandibular arch.
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DOI：
10.7554/elife.78170
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发表时间：
2022-06-28
期刊：
影响因子：
7.7
通讯作者：
Crump JG
中科院分区：
文献类型：
--
作者：
Thiruppathy M;Fabian P;Gillis JA;Crump JG
虽然没有已知的活脊椎动物拥有来自下颌弓的鳃，但有人提出下颌是通过修改祖先的下颌鳃而产生的。在这里，我们表明，斑马鱼pseudobranchin，调节血压的眼睛，从下颌弓间充质和第一袋上皮细胞和股票的基因表达，增强子的利用，和发展的gata3依赖与鳃。结合软骨鱼类的研究，我们在硬骨鱼类中的发现指出，在有颌脊椎动物的最后一个共同祖先中，下颌假鳃与鳃具有系列同源性，这与脊椎动物颌骨的鳃起源一致。
Whereas no known living vertebrate possesses gills derived from the jaw-forming mandibular arch, it has been proposed that the jaw arose through modifications of an ancestral mandibular gill. Here, we show that the zebrafish pseudobranch, which regulates blood pressure in the eye, develops from mandibular arch mesenchyme and first pouch epithelia and shares gene expression, enhancer utilization, and developmental gata3 dependence with the gills. Combined with work in chondrichthyans, our findings in a teleost fish point to the presence of a mandibular pseudobranch with serial homology to gills in the last common ancestor of jawed vertebrates, consistent with a gill origin of vertebrate jaws.