Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05.
Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05.
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来自湿地土壤来源的真菌 Aspergillus calidoustus TJ403-EL05 的 Drimane 倍半萜类化合物
DOI：
10.1007/s13659-022-00349-w
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发表时间：
2022-07-22
影响因子：
4.7
通讯作者：
Zhang, Yonghui
中科院分区：
文献类型：
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作者：
Zhang, Sitian;Mo, Shuyuan;Li, Fengli;Zhang, Yaxin;Wang, Jianping;Hu, Zhengxi;Zhang, Yonghui
土壤来源的真菌代表了发现新的和生物活性的天然产物（NP）的未充分开发的水库，尽管在过去的几十年中已经发现了越来越多的未知NP，但许多隐藏的生物合成潜力仍然迫切需要公开。本研究对一株湿地土壤源真菌Aspergillus calidoustus TJ 403-EL 05进行了化学成分的研究，共分离得到14个补身烷类倍半萜（1-14），其中包括3个新的补身烷类倍半萜（1-3），即ustusols F-H。它们的结构，包括绝对配置，完全通过广泛的光谱数据，量子化学13 C NMR和ECD计算，和X射线晶体学实验验证。化合物14通过抑制LPS诱导的NO释放表现出中等的抗炎活性（IC 50 = 25.6 μM）。在线版本包含补充材料，可通过10.1007/s13659-022-00349-w获得。
Soil-derived fungi represent an insufficiently tapped reservoir for discovering new and bioactive natural products (NPs), and despite an ever-increasing number of unknown NPs have been discovered over the past few decades, much of the hidden biosynthetic potential is still in an urgent need to be disclosed. In this research, a chemical investigation was performed on a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05, leading to the isolation of a total of fourteen drimane sesquiterpenoids (1–14), incorporating three new ones, namely ustusols F–H (1–3). Their structures, comprising absolute configurations, were completely authenticated by widespread spectroscopic data, quantum chemical 13C NMR and ECD calculations, and X-ray crystallography experiments. Compound 14 exhibited moderate anti-inflammatory activity by inhibiting the LPS-induced NO release (IC50 = 25.6 μM). The online version contains supplementary material available at 10.1007/s13659-022-00349-w.