From Here to There, Progenitor Cells and Stem Cells Are Everywhere in Lung Vascular Remodeling.
From Here to There, Progenitor Cells and Stem Cells Are Everywhere in Lung Vascular Remodeling.
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DOI：
10.3389/fped.2016.00080
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发表时间：
2016
影响因子：
2.6
通讯作者：
Farkas L
中科院分区：
文献类型：
--
作者：
Heise RL;Link PA;Farkas L
在过去的十年中，干细胞生物学、细胞治疗和再生医学领域几乎呈指数级增长。临床试验正在评估干细胞在许多具有血管成分的成人和儿童肺部疾病中的潜在治疗用途，例如支气管肺发育不良（BPD），慢性阻塞性肺病（COPD），特发性肺纤维化（IPF）或肺动脉高压（PAH）。广泛的研究活动正在探索肺驻留和循环祖细胞及其对慢性肺部疾病血管并发症的贡献，研究人员希望使用驻留或循环干/祖细胞治疗慢性肺部疾病及其血管并发症。越来越清楚的是，机械生物学的进展将有助于了解物理力和细胞外基质组成对祖细胞和干细胞表型和特征的各种影响。本次审查概述了该领域的当前概念。
The field of stem cell biology, cell therapy, and regenerative medicine has expanded almost exponentially, in the last decade. Clinical trials are evaluating the potential therapeutic use of stem cells in many adult and pediatric lung diseases with vascular component, such as bronchopulmonary dysplasia (BPD), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), or pulmonary arterial hypertension (PAH). Extensive research activity is exploring the lung resident and circulating progenitor cells and their contribution to vascular complications of chronic lung diseases, and researchers hope to use resident or circulating stem/progenitor cells to treat chronic lung diseases and their vascular complications. It is becoming more and more clear that progress in mechanobiology will help to understand the various influences of physical forces and extracellular matrix composition on the phenotype and features of the progenitor cells and stem cells. The current review provides an overview of current concepts in the field.