The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats
The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats
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DOI：
10.1016/j.neulet.2009.08.008
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发表时间：
2009-10-16
影响因子：
2.5
通讯作者：
Smith, Paul F.
中科院分区：
文献类型：
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作者：
Baek, Jean Ha;Zheng, Yiwen;Smith, Paul F.
据报道，作为大麻素CB 1受体激动剂的药物会干扰多种认知功能，包括物体识别记忆。然而，迄今为止，大多数关于记忆这方面的研究表明，这些影响主要发生在青春期或青春期前，而不是成年大鼠。在这项研究中，我们重新审视了这个问题，并评估了单次s.c.注射1、3或5 mg/kg CB 1受体激动剂WIN 55，212 -2（“WIN”），对物体识别记忆有影响。我们发现WIN仅在5 mg/kg剂量下显著减少了对物体的总探索时间（P < 0.05）。这可能是由于其在该剂量下的镇静作用。然而，控制WIN对物体探索的一般影响的辨别指数仅在1 mg/kg WIN组中显著降低（P < 0.05），表明仅在该低剂量下WIN特异性地干扰物体辨别。这些结果表明，WIN可以干扰物体识别记忆，即使在成年大鼠单次注射低剂量。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Drugs that act as agonists at the cannabinoid CB1 receptor have been reported to interfere with a diverse range of cognitive functions, including object recognition memory. However, to date, most of the studies conducted on this aspect of memory have suggested that these effects occur mainly in pubertal or pre-pubertal, rather than adult, rats. In this study we revisited this issue and evaluated the effects of a single s.c. injection of the CB1 receptor agonist, WIN 55,212-2 ('WIN'), at 1, 3 or 5 mg/kg, on object recognition memory. We found that WIN significantly reduced the total exploration time for objects at the 5 mg/kg dose only (P < 0.05). This was presumably due to its sedative effects at this dose. However, the discrimination index, which controlled for the general effects of WIN on object exploration, was significantly reduced only for the 1 mg/kg WIN group (P < 0.05), suggesting that only at this low dose did WIN specifically interfere with object discrimination. These results suggest that WIN can interfere with object recognition memory even in adult rats following a single injection of a low dose. (C) 2009 Elsevier Ireland Ltd. All rights reserved.