Vitiligo is associated with HLA-DR4 in black patients. A preliminary report.
Vitiligo is associated with HLA-DR4 in black patients. A preliminary report.
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DOI：
10.1001/archderm.1990.01670250062009
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发表时间：
1990
影响因子：
--
通讯作者：
Georgia M. Dunston;R. Halder
中科院分区：
文献类型：
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作者：
Georgia M. Dunston;R. Halder
我们确定了24例白癜风患者的HLA-DR和HLA-DQ表型，并与143例当地黑人对照的表型进行了比较。HLA-DR 4在患者中显著增加，38%对对照组的11%。HLA-DQw 3在患者中也增加，58%比对照组的32%，并且可以部分地通过与HLA-DR 4的连锁不平衡来解释。当患者根据自身免疫性疾病家族史进行亚组化并与对照组比较时，HLA-DR 4和HLA-DQw 3的增加与阳性家族史分离。HLA-DRw 6在自身免疫性疾病家族史阴性的患者中（64%）显著高于家族史阳性的患者（10%）。当患者根据发病时的年龄进行亚组时，HLA-DR 4在早期发病（小于20岁）的患者中增加，而HLA-DRw 6在发病时年龄较大的患者中更大。这些发现支持了免疫遗传学影响白癜风在黑人白癜风患者中表达的假设。
We have determined the HLA-DR and HLA-DQ phenotypes of 24 black patients with vitiligo and compared these with phenotypes of 143 local black controls. HLA-DR4 was significantly increased in patients, 38% vs 11% for controls. HLA-DQw3 was also increased in patients, 58% vs 32% for controls and may be explained in part by linkage disequilibrium with HLA-DR4. When patients were subgrouped according to family history of autoimmune disease and compared with controls, the increase in HLA-DR4 and HLA-DQw3 segregated with a positive family history. HLA-DRw6 in patients with a negative family history of autoimmune disease (64%) was significantly greater than the 10% in patients with a positive family history. When patients were subgrouped according to age at onset of disease, HLA-DR4 was increased in those with early onset of disease (younger than 20 years) while HLA-DRw6 was greater in patients who were older at onset of disease. These findings support the hypothesis of an immunogenetic influence on the expression of vitiligo in black patients with vitiligo.