Response of large and small coronary arteries to nitroglycerin, NaNO 2 , and adenosine.
Response of large and small coronary arteries to nitroglycerin, NaNO 2 , and adenosine.
复制标题
大、小冠状动脉对硝酸甘油、NaNO 2 和腺苷的反应。
DOI：
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发表时间：
1972
影响因子：
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通讯作者：
H. Sparks
中科院分区：
文献类型：
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作者：
R. Schnaar;H. Sparks
罗纳德·希纳尔哈维诉斯帕克斯案。大小冠状动脉对硝酸甘油、NaNO 2和腺苷的反应。Am. J.Physiol.223（l）：223-228. 1972.-将大（2 mm OD）和小（.5 mm OD）冠状动脉条并排安装在肌肉浴中。使KCl浓度达到35 mM以产生张力，并测量等长张力。响应表示为由无钙生理盐溶液引起的最大松弛的百分比。硝酸钠和硝酸甘油对大血管的舒张作用大于小血管（P < 0.05）。腺苷对小血管的舒张作用大于大血管（P < 0.05）。用等渗高钾（100 mM K&04）溶液去极化并没有减少响应于硝酸甘油或腺苷的松弛，这表明松弛可以在细胞膜的电状态没有变化的情况下发生。腺苷和硝酸甘油对Ca++诱导的收缩的影响表明，腺苷对大动脉和小动脉的不同作用可能是通过对Ca ++流量的不同作用来解释的，但硝酸甘油的不同作用可能不能用这种方式来解释。这项研究支持在原位工作表明大，小冠状动脉血管平滑肌硝酸甘油的反应的差异。
SCHNAAR, RONALD L., AND HARVEY V. SPARKS. Response of large and small coronary arteries to nitroglycerin, NaNO2, and adenosine. Am. J. Physiol. 223(l) : 223-228. 1972.-Large (2 mm od) and small (.5 mm od) coronary artery strips were mounted side by side in a muscle bath. KC1 concentration was brought to 35 mM to produce tone and isometric tension was measured. Responses were expressed as the percent of the maximum relaxation caused by calcium-free physiological salt solution. NaNOz and nitroglycerin caused greater relaxation of large vessels than small (P < 0.05). Adenosine caused greater relaxation of small vessels than large vessels (P < 0.05). Depolarization with an isotonic high potassium (100 mM K&04) solution did not reduce the relaxation in response to nitroglycerin or adenosine, suggesting that relaxation can occur without changes in the electrical state of the cell membrane. The effects of adenosine and nitroglycerin on Ca++-induced contraction suggest that the differential effect of adenosine on large and small arteries may be explained by different effects on Ca ++ flux, but that the differential effect of nitroglycerin may not be explained in this way. This study supports in situ work suggesting differences in the response of vascular smooth muscle of large and small coronary arteries to nitroglycerin.