General Principle for Fabricating Natural Globular Protein-Based Double-Network Hydrogels with Integrated Highly Mechanical Properties and Surface Adhesion on Solid Surfaces
General Principle for Fabricating Natural Globular Protein-Based Double-Network Hydrogels with Integrated Highly Mechanical Properties and Surface Adhesion on Solid Surfaces
复制标题
制备具有综合高机械性能和固体表面表面粘附力的天然球状蛋白质双网络水凝胶的一般原理
DOI：
10.1021/acs.chemmater.8b03860
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发表时间：
2019-01-08
影响因子：
8.6
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
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作者：
Tang, Ziqing;Chen, Qiang;Zheng, Jie
将球状蛋白和合成聚合物的功能杂合体开发成多用途的坚韧水凝胶仍然具有挑战性。在此，我们提出了一种结合双网络和蛋白质错误折叠概念的新策略，以创建具有高体积和界面韧性的多种蛋白质聚合物双网络（DN）水凝胶。该方法将固有的热诱导蛋白变性/聚集特性与双网络概念相结合，通过混合物理化学交联或完全物理交联制备出不同的基于牛血清白蛋白（BSA）的DN水凝胶，可实现高模量252-1199 kPa，高强度0.24-0.48 MPa，高断裂能3.56-16.88 MJ/m(3)，高伸长率7.7-79.9 mm/mm。自恢复快（80℃热处理30 min后刚度/韧性恢复94/80%），对各种无孔固体表面具有很强的表面附着力（界面韧性为1176-2827 J/m(2)）。这种坚韧且具有粘性的蛋白质-聚合物水凝胶在人造软组织、柔性电子产品和可穿戴设备等不同应用领域具有巨大的潜力。
Developing functional hybrids of globular proteins and synthetic polymers into multipurpose tough hydrogels remains challenging. Here, we propose a new strategy combining double-network and protein misfolding concepts to create diverse protein polymer double-network (DN) hydrogels with both high bulk and interfacial toughness. The method integrates an intrinsic heat-induced protein denaturation/aggregation feature and a double-network concept, which produces different bovine serum albumin (BSA)-based DN hydrogels with hybrid physical chemical cross linking or fully physical cross-linking to achieve a high modulus of 252-1199 kPa, high strength of 0.24-0.48 MPa, high fracture energy of 3.56-16.88 MJ/m(3), high extensibility of 7.7-79.9 mm/mm, fast self-recovery (stiffness/toughness recovery of 94/80% after heat treatment at 80 degrees C for 30 min), and strong surface adhesion to various nonporous solid surfaces (interfacial toughness of 1176-2827 J/m(2)). Such tough and adhesive protein-polymer hydrogels have great potential for different applications, such as artificial soft tissues, flexible electronics, and wearable devices.