A1 Noradrenergic Neurons Lesions Reduce Natriuresis and Hypertensive Responses to Hypernatremia in Rats
A1 Noradrenergic Neurons Lesions Reduce Natriuresis and Hypertensive Responses to Hypernatremia in Rats
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DOI：
10.1371/journal.pone.0073187
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发表时间：
2013-09-10
期刊：
影响因子：
3.7
通讯作者：
Pedrino, Gustavo Rodrigues
中科院分区：
文献类型：
--
作者：
da Silva, Elaine Fernanda;Freiria-Oliveira, Andre Henrique;Pedrino, Gustavo Rodrigues
Noradrenergic neurons in the caudal ventrolateral medulla (CVLM; A1 group) contribute to cardiovascular regulation. The present study assessed whether specific lesions in the A1 group altered the cardiovascular responses that were evoked by hypertonic saline (HS) infusion in non-anesthetized rats. Male Wistar rats (280-340 g) received nanoinjections of antidopamine-beta-hydroxylase-saporin (A1 lesion, 0.105 ng.nL(-1)) or free saporin (sham, 0.021 ng.nL(-1)) into their CVLMs. Two weeks later, the rats were anesthetized (2% halothane in O-2) and their femoral artery and vein were catheterized and led to exit subcutaneously between the scapulae. On the following day, the animals were submitted to HS infusion (3 M NaCl, 1.8 ml . kg(-1), b.wt., for longer than 1 min). In the sham-group (n = 8), HS induced a sustained pressor response (Delta MAP: 35 +/- 3.6 and 11 +/- 1.8 mmHg, for 10 and 90 min after HS infusion, respectively; P
